Technology Process of 3'-amino-2'-hydroxy-biphenyl-3-carboxylic acid hydrobromide
There total 5 articles about 3'-amino-2'-hydroxy-biphenyl-3-carboxylic acid hydrobromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen bromide;
at 120 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium nitrate; sulfuric acid / water / 2 h / 20 - 25 °C
2: potassium carbonate / acetone / 40 h / 70 °C
3: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 43 h / 105 °C
4: ammonium formate / palladium 10% on activated carbon / ethanol / 0.33 h / 80 °C
5: hydrogen bromide / water / 120 °C
With
sodium nitrate; sulfuric acid; hydrogen bromide; ammonium formate; sodium carbonate; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
1,4-dioxane; ethanol; water; acetone;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / acetone / 40 h / 70 °C
2: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 43 h / 105 °C
3: ammonium formate / palladium 10% on activated carbon / ethanol / 0.33 h / 80 °C
4: hydrogen bromide / water / 120 °C
With
hydrogen bromide; ammonium formate; sodium carbonate; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon;
In
1,4-dioxane; ethanol; water; acetone;