6?(1,3?diphenyl?1H?pyrazol?4?yl)?4?oxo?2?thioxo?1,2,3,4?tetrahydropyrimidine?5?carbonitrile

Base Information

Chemical Name:6?(1,3?diphenyl?1H?pyrazol?4?yl)?4?oxo?2?thioxo?1,2,3,4?tetrahydropyrimidine?5?carbonitrile
CAS No.:947490-12-2
Molecular Formula:C₂₀H₁₃N₅OS
Molecular Weight:371.422
Hs Code.:

Synonyms:6?(1,3?diphenyl?1H?pyrazol?4?yl)?4?oxo?2?thioxo?1,2,3,4?tetrahydropyrimidine?5?carbonitrile

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Chemical Property of 6?(1,3?diphenyl?1H?pyrazol?4?yl)?4?oxo?2?thioxo?1,2,3,4?tetrahydropyrimidine?5?carbonitrile

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Technology Process of 6?(1,3?diphenyl?1H?pyrazol?4?yl)?4?oxo?2?thioxo?1,2,3,4?tetrahydropyrimidine?5?carbonitrile

There total 5 articles about 6?(1,3?diphenyl?1H?pyrazol?4?yl)?4?oxo?2?thioxo?1,2,3,4?tetrahydropyrimidine?5?carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 17356-08-0
thiourea

: 105-56-6
ethyl 2-cyanoacetate

: 21487-45-6
1,3-diphenyl-4-formylpyrazole

: 947490-12-2
6?(1,3?diphenyl?1H?pyrazol?4?yl)?4?oxo?2?thioxo?1,2,3,4?tetrahydropyrimidine?5?carbonitrile

Guidance literature:: With potassium carbonate; In ethanol; for 12h; Heating;
DOI:10.1080/10426500600754695

Reference yield: 29.0%

: 2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl)propenoyl chloride

: 17356-08-0
thiourea

: 947490-12-2
6?(1,3?diphenyl?1H?pyrazol?4?yl)?4?oxo?2?thioxo?1,2,3,4?tetrahydropyrimidine?5?carbonitrile

: N?carbamothioyl?2?cyano?3?(1,3?diphenyl?1H?pyrazol?4?yl)acrylamide

Guidance literature:: With triethylamine; In benzene; for 2h; Reflux;
DOI:10.1007/s13738-020-01873-7

Reference yield:

: 21487-45-6
1,3-diphenyl-4-formylpyrazole

: 947490-12-2
6?(1,3?diphenyl?1H?pyrazol?4?yl)?4?oxo?2?thioxo?1,2,3,4?tetrahydropyrimidine?5?carbonitrile

: N?carbamothioyl?2?cyano?3?(1,3?diphenyl?1H?pyrazol?4?yl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine / ethanol / 20 °C

2: sodium hydroxide / ethanol / 1 h / 20 °C

3: thionyl chloride / 4 h / 65 °C

4: triethylamine / benzene / 2 h / Reflux

With piperidine; thionyl chloride; triethylamine; sodium hydroxide; In ethanol; benzene;
DOI:10.1007/s13738-020-01873-7