21487-45-6

Basic information

• Product Name: 1,3-DIPHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
• Synonyms: 1,3-DIPHENYL-1H-PYRAZOLE-4-CARBOXALDEHY&;1,3-Diphenyl-1H-pyrazole-4-carboxaldehyde;1,3-diphenyl-1H-pyrazole-4-carbaldehyde(SALTDATA: FREE);1,3-Diphenylpyrazole-4-carboxaldehyde;1,3-Diphenyl-1H-pyrazole-4-carboxaldehyde 97%;1,3-di(phenyl)-4-pyrazolecarboxaldehyde;1,3-di(phenyl)pyrazole-4-carbaldehyde;1,3-Diphenyl-4-pyrazolecarboxaldehyde
• CAS NO: 21487-45-6
• Molecular Formula: C₁₆H₁₂N₂O
• Molecular Weight: 248.27928
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrazoles
• Mol File: 21487-45-6.mol
• Article Data: 137

Chemical Properties

• Melting Point: 142-146 °C
• Boiling Point: 442.2°Cat760mmHg
• Flash Point: 221.2°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 5.13E-08mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1,3-DIPHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DIPHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(21487-45-6)
• EPA Substance Registry System: 1,3-DIPHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(21487-45-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41-37/38
• Safety Statements: 26-36/37/39-39
• WGK Germany: 3
• Hazardous Substances Data: 21487-45-6(Hazardous Substances Data)

Usage

Uses

1,3-Diphenyl-4-pyrazolecarboxaldehyde is used in the?synthesis of asymmetric thiazolyl pyrazolines as a potential antioxidant and anti-Inflammatory agents.

InChI:InChI=1/C16H12N2O/c19-12-14-11-18(15-9-5-2-6-10-15)17-16(14)13-7-3-1-4-8-13/h1-12H

Upstream product

• 4492-01-7 1,3-diphenyl-1H-pyrazole 
• 68-12-2 N,N-dimethyl-formamide 
• 176387-56-7 5-amino-1,3-diphenyl-1H-pyrazole-4-carboxaldehyde 
• 583-11-9 N-(1-phenylethylidene)phenylhydrazine 
• 588-64-7 benzaldehyde phenylhydrazone 
• 98-86-2 acetophenone 
• 100-63-0 phenylhydrazine 
• 18997-06-3 N,N-Dimethyl-formamide; compound with GENERIC INORGANIC NEUTRAL COMPONENT 
• 7409-31-6 4-bromo-3-hydroxy-1-phenyl-1H-pyrazole 
• 1008-79-3 1-phenyl-1H-pyrazol-3-ol 
• 1354413-51-6 4-formyl-1-phenyl-1H-pyrazol-3-yl trifluoromethanesulfonate 
• 98-80-6 phenylboronic acid 
• 1354413-50-5 3-(benzyloxy)-1-phenyl-1H-pyrazol 
• 464185-13-5 3-(benzyloxy)-1-phenyl-1H-pyrazole-4-carbaldehyde 

Downstream Products

• 144119-16-4 1-(1,3-diphenyl-1H-pyrazol-4-yl)-N-(p-tolyl)methanimine 
• 144119-20-0 (4-chlorophenyl)[(1,3-diphenylpyrazol-4-yl)methylene]amine 
• 144119-23-3 [1-(1,3-Diphenyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-(4-methoxy-phenyl)-amine 
• 144119-22-2 (2-Chloro-phenyl)-[1-(1,3-diphenyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-amine 
• 73221-47-3 (E)-3-(1,3-Diphenyl-1H-pyrazol-4-yl)-acrylic acid 
• 108446-65-7 2-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)malonic acid 
• 144119-24-4 3-ethyl-1-(1,3-diphenyl-4-pyrazolyl)-1-propen-3-one 
• 144119-18-6 [(1,3-diphenylpyrazol-4-yl)methylene](o-tolyl)amine 
• 108446-83-9 2-(1,3-Diphenyl-1H-pyrazol-4-ylmethylene)-malonic acid diethyl ester 
• 112767-32-5 4-(1,3-Diphenyl-1H-pyrazol-4-yl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 

Relevant articles and documents

Synthesis and evaluation of pyrazole-incorporated monocarbonyl curcumin analogues as antiproliferative and antioxidant agents

A series of pyrazole-incorporated monocarbonyl analogues of curcumin were synthesized via Clasien–Schimidt-type condensation and subsequently screened for in vitro antiproliferative and antioxidant activity. The analogues 4c, 5d, 5e, 5g, 6e, and 6f showed

Synthesis, Characterization, and Comparative Study of Some Heterocyclic Compounds Containing Isoniazid and Nicotinic Acid Hydrazide Moieties

Abstract: Some new derivatives of six-membered heterocyclic compounds containingisoniazid and nicotinic acid hydrazide fragments have been synthesized accordingto green procedures with excellent yields. The structures of the synthesizedcompounds were conf

Urea derivatives of piperazine doped with pyrazole-4-carboxylic acids: Synthesis and antimicrobial evaluation

A series of novel N-cycloalkyl/aryl-4-(1,3-diphenyl-1H-pyrazole-4-carbonyl)piperazine-1-carboxamides 9a-g has been synthesized for biological interest by simple base catalyzed reaction of various N-cycloalkyl/aryl isocyanates with (1,3-diphenyl-1H-pyrazol

Synthesis of some new 2-(3-aryl-1-phenyl-4-pyrazolyl)benzoxazoles using hypervalent iodine mediated oxidative cyclization of schiff's bases

Ten new 2-(3-aryl-1-phenyl-4-pyrazolyl)benzoxazoles have been synthesized by oxidative intramolecular cyclization of the corresponding Schiff's bases using iodobenzene diacetate in methanol as an oxidant.

New 4-fluoroalkyl substituted N-phenylpyrazoles: Synthesis promoted by DAST and multinuclear NMR analysis

This paper reports a synthetic and NMR spectroscopic studies of two new series of 4-fluorinated 1,3,5-substituted 1H-pyrazoles. Firstly, an efficient synthesis of new series of 3-aryl-4-(di)fluoromethyl-1H-1-phenylpyrazoles, where [aryl = Ph, 4-NO2/

Antispasmodic and antimicrobial activities of pyrazole-containing ferrocenyl alkanols versus their phenyl analogs, and the entry point to potential multitarget treatment for inflammatory bowel diseases

Inflammatory bowel diseases (IBM), such as Crohn's disease, and their common complications represent a global health challenge. Many pyrazole derivatives, such as the spasmolytic drug metamizole, have already found their place among the frequently used th

Synthesis, Characterization, and Biological Evolution of New Pyrazole Derivatives of 4-(4-Aminophenyl)morpholin-3-one through Ugi Reaction

A new heterocyclic library was synthesized using multicomponent reactions (MCRs). A green strategy during which a set of molecules with an excellent diversity is generated with a minimum of synthetic effort, time, and by-products formation. This new series prepared using the Ugi MCRs in which aldehyde, amine, acid, and isocyanide reacts to make α-bisamide. During this work, we practice the Ugi reaction to synthesize an extremely functionalized heterocyclic library which was characterized and tested for biological evaluation. This innovative synthetic route involves for pyrazole derivatives of 4-(4-aminophenyl)morpholin-3-one by Ugi four component reaction and methanol as a solvent in good yield and high purity. All the produced compounds of library were characterized using 1H-NMR, IR, and mass spectroscopic methods.