21487-45-6

Usage

Uses

1. Used in Pharmaceutical Industry:
1,3-Diphenyl-1H-pyrazole-4-carbaldehyde is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
2. Used in Synthesis of Asymmetric Thiazolyl Pyrazolines:
1,3-Diphenyl-1H-pyrazole-4-carbaldehyde is used as a starting material for the synthesis of asymmetric thiazolyl pyrazolines. These compounds have shown potential as antioxidant and anti-inflammatory agents, making them valuable in the development of new treatments for various diseases and conditions.
3. Used in Organic Chemistry Research:
Due to its unique structure and reactivity, 1,3-diphenyl-1H-pyrazole-4-carbaldehyde can be used as a building block in organic chemistry research. It can be employed in the synthesis of various complex organic molecules, contributing to the advancement of chemical knowledge and the development of new materials and compounds.

InChI:InChI=1/C16H12N2O/c19-12-14-11-18(15-9-5-2-6-10-15)17-16(14)13-7-3-1-4-8-13/h1-12H

Upstream product

• 59130-82-4 acetophenone phenylhydrazone 
• 68-12-2 N,N-dimethyl-formamide 
• 98-86-2 acetophenone 
• 100-63-0 phenylhydrazine 
• 4492-01-7 1,3-diphenyl-1H-pyrazole 
• 3724-43-4 Vilsmeier reagent 
• 583-11-9 N-(1-phenylethylidene)phenylhydrazine 
• 176387-56-7 5-amino-1,3-diphenyl-1H-pyrazole-4-carboxaldehyde 
• 588-64-7 benzaldehyde phenylhydrazone 
• 18997-06-3 N,N-Dimethyl-formamide; compound with GENERIC INORGANIC NEUTRAL COMPONENT 
• 7409-31-6 4-bromo-3-hydroxy-1-phenyl-1H-pyrazole 
• 1008-79-3 1-phenyl-1H-pyrazol-3-ol 
• 1354413-51-6 4-formyl-1-phenyl-1H-pyrazol-3-yl trifluoromethanesulfonate 
• 98-80-6 phenylboronic acid 

Downstream Products

• 51571-43-8 4-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)-2-phenyloxazol-5-one 
• 144119-20-0 (4-chlorophenyl)[(1,3-diphenylpyrazol-4-yl)methylene]amine 
• 144119-23-3 [1-(1,3-Diphenyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-(4-methoxy-phenyl)-amine 
• 144118-63-8 1-phenyl-3-(1,3-diphenyl-1H-pyrazole-4-yl)prop-2-en-1-one 
• 144119-17-5 (3-Chloro-phenyl)-[1-(1,3-diphenyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-amine 
• 221619-42-7 2-[(1,3-diphenyl-1H-pyrazol-4-yl)methylidene]hydrazine-1-carbothioamide 
• 221619-37-0 [(1,3-diphenyl-1H-pyrazol-4-yl)methylidene]propanedinitrile 
• 302936-47-6 Benzyl-[1-(1,3-diphenyl-1H-pyrazol-4-yl)-meth-(E)-ylidene]-amine 
• 77169-12-1 1,3-diphenyl-1H-pyrazole-4-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and evaluation of pyrazole-incorporated monocarbonyl curcumin analogues as antiproliferative and antioxidant agents

A series of pyrazole-incorporated monocarbonyl analogues of curcumin were synthesized via Clasien–Schimidt-type condensation and subsequently screened for in vitro antiproliferative and antioxidant activity. The analogues 4c, 5d, 5e, 5g, 6e, and 6f showed

Unexpected Metal-Free Fluorination and Oxidation at the C-4 Position of Pyrazoles Promoted by Selectfluor

Metal-free electrophilic fluorination, promoted by Selectfluor, of pyrazoles with methylene groups (CH2X), in which XA =A OH, OMe, F, N3, and NHMe at the C-4 position furnished the 4-fluoro-pyrazole products from unexpected C-C bond cleavage, at moderate to good yields. Otherwise, under the same reaction conditions, when XA =A NEt2 or SPr, the oxidation product 4-formyl-pyrazole was obtained.

Synthesis, Characterization, and Comparative Study of Some Heterocyclic Compounds Containing Isoniazid and Nicotinic Acid Hydrazide Moieties

Abstract: Some new derivatives of six-membered heterocyclic compounds containingisoniazid and nicotinic acid hydrazide fragments have been synthesized accordingto green procedures with excellent yields. The structures of the synthesizedcompounds were conf

Solubility and solution thermodynamics of novel pyrazolo chalcone derivatives in various solvents from 298.15?K to 328.15?K

Some novel pyrazolo chalcone derivatives have been synthesized and characterization of these synthesized compounds was done by IR, 1H NMR, 13C NMR and mass analysis. The solubility of pyrazolo chalcone derivatives in methanol, ethanol, 1-propanol, 1-butanol, 1-pentanol, ethyl acetate and acetonitrile was measured by gravimetric method over a temperature range (298.15 to 328.15) K at atmospheric pressure. The solubility of synthesized compounds is found to increase linearly with temperature. Further, in alcoholic solvents, solubility is maximum in 1-pentanol and minimum in methanol whereas in non-alcoholic solvents, solubility is greater in ethyl acetate and minimum in acetonitrile. The experimental solubility data were correlated with temperature by modified Apelblat and Buchowski-Ksiazczak λh equations. The experimental data and model parameters would be useful for optimizing the process of purification. Some thermodynamic parameters such as dissolution enthalpy, Gibb's free energy and entropy of mixing have also been calculated by Van't Hoff analysis. Further, excess enthalpy of solutions has been calculated using Buchowski-Ksiazczak λh equation.

Urea derivatives of piperazine doped with pyrazole-4-carboxylic acids: Synthesis and antimicrobial evaluation

A series of novel N-cycloalkyl/aryl-4-(1,3-diphenyl-1H-pyrazole-4-carbonyl)piperazine-1-carboxamides 9a-g has been synthesized for biological interest by simple base catalyzed reaction of various N-cycloalkyl/aryl isocyanates with (1,3-diphenyl-1H-pyrazol

Pd-catalyzed post-Ugi intramolecular cyclization to the synthesis of isoquinolone-pyrazole hybrid pharmacophores & discover their antimicrobial and DFT studies

A novel microwave assisted ligand-free palladium-catalyzed post Ugi reaction for the synthesis of isoquinolone and pyrazole mixed pharmacophore derivatives was achieved from isocyanide and pyrazole substituted amide molecules (synthesized by using Ugi rea

Synthesis of some new 2-(3-aryl-1-phenyl-4-pyrazolyl)benzoxazoles using hypervalent iodine mediated oxidative cyclization of schiff's bases

Ten new 2-(3-aryl-1-phenyl-4-pyrazolyl)benzoxazoles have been synthesized by oxidative intramolecular cyclization of the corresponding Schiff's bases using iodobenzene diacetate in methanol as an oxidant.

An ionic receptor for Zn2+ metal ion using synthesised bis-formylpyrazole calix[4]arene and its computational study

Newly synthesised receptor Bis-(1,3-diphenyl-pyrazolyl methylene acetohydrazide)Calix[4]arene (DPPMACA) was evaluated for cation binding ability. The receptor DPPMACA selectively interact with Zn2+ metal ion as assessed through UV-visible spect

New 4-fluoroalkyl substituted N-phenylpyrazoles: Synthesis promoted by DAST and multinuclear NMR analysis

This paper reports a synthetic and NMR spectroscopic studies of two new series of 4-fluorinated 1,3,5-substituted 1H-pyrazoles. Firstly, an efficient synthesis of new series of 3-aryl-4-(di)fluoromethyl-1H-1-phenylpyrazoles, where [aryl = Ph, 4-NO2/

A smart chemosensor: Discriminative multidetection and various logic operations in aqueous solution at biological pH

A novel rhodamine-pyrazole based molecular probe was designed and easily synthesized. The probe could to detect several analytes in aqueous solution at biological pH (HEPES, pH = 7.2). Several heavy metal cations, including Cu2+, Fe3+/sup