Phosphoric acid 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester (2R,3R,4R,5R)-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester

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Chemical Name:Phosphoric acid 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester (2R,3R,4R,5R)-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester
CAS No.:117901-72-1
Molecular Formula:C₄₈H₄₁Cl₃N₃O₁₀PS
Molecular Weight:989.266
Hs Code.:

Phosphoric acid 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester (2R,3R,4R,5R)-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester

Synonyms:Phosphoric acid 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester (2R,3R,4R,5R)-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester

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Chemical Property of Phosphoric acid 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester (2R,3R,4R,5R)-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester

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Technology Process of Phosphoric acid 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester (2R,3R,4R,5R)-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester

There total 8 articles about Phosphoric acid 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester (2R,3R,4R,5R)-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 117901-71-0
Phosphoric acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester

: 117901-72-1
Phosphoric acid 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester (2R,3R,4R,5R)-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester

Guidance literature:: With toluene-4-sulfonic acid; In methanol; dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1246/cl.1988.857

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 117901-72-1
Phosphoric acid 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester (2R,3R,4R,5R)-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: p-toluenesulfonic acid monohydrate / dioxane / 2 h

2: 1M tributylammonium hydrogen fluoride / 3 h / Ambient temperature

3: pyridine

4: 86 percent

5: 85 percent / 2percent TsOH / CH₂Cl₂; methanol / 0.17 h / 0 °C

With pyridine; tri-n-butylamine hydrofluoride; toluene-4-sulfonic acid; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1246/cl.1988.857

Reference yield:

: 24165-03-5
tritylsulfenyl chloride

: 117901-72-1
Phosphoric acid 5-chloro-quinolin-8-yl ester 2,6-dichloro-phenyl ester (2R,3R,4R,5R)-5-(2,4-dioxo-3-tritylsulfanyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 75 percent / triethylamine / CH₂Cl₂ / 8 h / Ambient temperature

2: p-toluenesulfonic acid monohydrate / dioxane / 2 h

3: 1M tributylammonium hydrogen fluoride / 3 h / Ambient temperature

4: pyridine

5: 86 percent

6: 85 percent / 2percent TsOH / CH₂Cl₂; methanol / 0.17 h / 0 °C

With pyridine; tri-n-butylamine hydrofluoride; toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1246/cl.1988.857