[1-[[3-(1,1-dimethylethyl)-phenyl]sulfonyl]-5-trifluoromethyl-1H-indol-2-yl]-methanol

Base Information

Chemical Name:[1-[[3-(1,1-dimethylethyl)-phenyl]sulfonyl]-5-trifluoromethyl-1H-indol-2-yl]-methanol
CAS No.:1274940-47-4
Molecular Formula:C₂₀H₂₀F₃NO₃S
Molecular Weight:411.445
Hs Code.:

Synonyms:[1-[[3-(1,1-dimethylethyl)-phenyl]sulfonyl]-5-trifluoromethyl-1H-indol-2-yl]-methanol

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Chemical Property of [1-[[3-(1,1-dimethylethyl)-phenyl]sulfonyl]-5-trifluoromethyl-1H-indol-2-yl]-methanol

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Technology Process of [1-[[3-(1,1-dimethylethyl)-phenyl]sulfonyl]-5-trifluoromethyl-1H-indol-2-yl]-methanol

There total 1 articles about [1-[[3-(1,1-dimethylethyl)-phenyl]sulfonyl]-5-trifluoromethyl-1H-indol-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(2-iodo-4-(trifluoromethyl)-phenyl)-3-(1,1-dimethylethyl)-benzene-sulfonamide: 1203588-23-1
N-(2-iodo-4-(trifluoromethyl)-phenyl)-3-(1,1-dimethylethyl)-benzene-sulfonamide

: 107-19-7
propargyl alcohol

: 1274940-47-4
[1-[[3-(1,1-dimethylethyl)-phenyl]sulfonyl]-5-trifluoromethyl-1H-indol-2-yl]-methanol

Guidance literature:: With diethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; for 1h; Reflux;

Reference yield: 87.0%

: 1274940-47-4
[1-[[3-(1,1-dimethylethyl)-phenyl]sulfonyl]-5-trifluoromethyl-1H-indol-2-yl]-methanol

: 1274940-52-1
2-bromomethyl-1-[[3-(1,1-dimethylethyl)-phenyl]sulfonyl]-5-trifluoromethyl-1H-indole

Guidance literature:: With phosphorus tribromide; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1274940-47-4
[1-[[3-(1,1-dimethylethyl)-phenyl]sulfonyl]-5-trifluoromethyl-1H-indol-2-yl]-methanol

: 1274940-59-8
5-[[1-[[3-(1,1-dimethylethyl)-phenyl]sulfonyl]-5-trifluoromethyl-1H-indol-2-yl]methyl]-furan-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus tribromide / dichloromethane / 1 h / 0 - 20 °C

2: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; ethanol / 0.33 h / 120 °C / Microwave irradiation

With phosphorus tribromide; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; ethanol; dichloromethane; 2: Suzuki Coupling;