1-(4-(5-amino-2-(4-fluorophenyl)thiazolo[4,5-d]pyrimidin-7-yl)-piperazin-1-yl)-2-(4-chlorophenoxy)ethanone

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Chemical Name:1-(4-(5-amino-2-(4-fluorophenyl)thiazolo[4,5-d]pyrimidin-7-yl)-piperazin-1-yl)-2-(4-chlorophenoxy)ethanone
CAS No.:1262121-00-5
Molecular Formula:C₂₃H₂₀ClFN₆O₂S
Molecular Weight:498.968
Hs Code.:

Synonyms:1-(4-(5-amino-2-(4-fluorophenyl)thiazolo[4,5-d]pyrimidin-7-yl)-piperazin-1-yl)-2-(4-chlorophenoxy)ethanone

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Chemical Property of 1-(4-(5-amino-2-(4-fluorophenyl)thiazolo[4,5-d]pyrimidin-7-yl)-piperazin-1-yl)-2-(4-chlorophenoxy)ethanone

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Technology Process of 1-(4-(5-amino-2-(4-fluorophenyl)thiazolo[4,5-d]pyrimidin-7-yl)-piperazin-1-yl)-2-(4-chlorophenoxy)ethanone

There total 5 articles about 1-(4-(5-amino-2-(4-fluorophenyl)thiazolo[4,5-d]pyrimidin-7-yl)-piperazin-1-yl)-2-(4-chlorophenoxy)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1262120-93-3
2-(4-fluorophenyl)-7-(piperazin-1-yl)thiazolo[4,5-d]pyrimidin-5-amine

: 4122-68-3
4-chlorophenyloxyacetyl chloride

: 1262121-00-5
1-(4-(5-amino-2-(4-fluorophenyl)thiazolo[4,5-d]pyrimidin-7-yl)-piperazin-1-yl)-2-(4-chlorophenoxy)ethanone

Guidance literature:: With pyridine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm101254z

Reference yield:

: 1262120-90-0
1-(4-(2,5-diaminothiazolo[4,5-d]pyrimidin-7-yl)piperazin-1-yl)-ethanone

: 1262121-00-5
1-(4-(5-amino-2-(4-fluorophenyl)thiazolo[4,5-d]pyrimidin-7-yl)-piperazin-1-yl)-2-(4-chlorophenoxy)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid; acetic acid; sodium nitrite / 0.5 h / 40 °C

1.2: 0.5 h / 80 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 100 °C / Inert atmosphere

3.1: hydrogenchloride / water / 4 h / 100 °C

4.1: pyridine / N,N-dimethyl-formamide / 2 h / 20 °C

With pyridine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; potassium carbonate; acetic acid; sodium nitrite; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1.2: Sandmeyer reaction / 2.1: Suzuki coupling;
DOI:10.1021/jm101254z

Reference yield:

: 1262120-91-1
1-(4-(5-amino-2-chlorothiazolo[4,5-d]pyrimidin-7-yl)piperazin-1-yl)ethanone

: 1262121-00-5
1-(4-(5-amino-2-(4-fluorophenyl)thiazolo[4,5-d]pyrimidin-7-yl)-piperazin-1-yl)-2-(4-chlorophenoxy)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 100 °C / Inert atmosphere

2: hydrogenchloride / water / 4 h / 100 °C

3: pyridine / N,N-dimethyl-formamide / 2 h / 20 °C

With pyridine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1021/jm101254z