{4-[4'-(5-chloro-1H-benzimidazol-2-yl)biphenyl-4-yl]piperazin-1-yl}acetic acid

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Chemical Name:{4-[4'-(5-chloro-1H-benzimidazol-2-yl)biphenyl-4-yl]piperazin-1-yl}acetic acid
CAS No.:1388142-58-2
Molecular Formula:C₂₅H₂₃ClN₄O₂
Molecular Weight:446.936
Hs Code.:

Synonyms:{4-[4'-(5-chloro-1H-benzimidazol-2-yl)biphenyl-4-yl]piperazin-1-yl}acetic acid

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Chemical Property of {4-[4'-(5-chloro-1H-benzimidazol-2-yl)biphenyl-4-yl]piperazin-1-yl}acetic acid

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Technology Process of {4-[4'-(5-chloro-1H-benzimidazol-2-yl)biphenyl-4-yl]piperazin-1-yl}acetic acid

There total 4 articles about {4-[4'-(5-chloro-1H-benzimidazol-2-yl)biphenyl-4-yl]piperazin-1-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1388144-39-5
5-chloro-2-(4'-piperazin-1-ylbiphenyl-4-yl)-1H-benzoimidazole

: 105-36-2
ethyl bromoacetate

: 1388142-58-2
{4-[4'-(5-chloro-1H-benzimidazol-2-yl)biphenyl-4-yl]piperazin-1-yl}acetic acid

Guidance literature:: 5-chloro-2-(4'-piperazin-1-ylbiphenyl-4-yl)-1H-benzoimidazole; ethyl bromoacetate; With potassium carbonate; In dimethyl sulfoxide; at 110 ℃; for 1h; Microwave irradiation;

With water; lithium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 16h;

With acetic acid; pH=5;

Reference yield:

: 470478-90-1
tert-butyl 4-[4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate

: 1388142-58-2
{4-[4'-(5-chloro-1H-benzimidazol-2-yl)biphenyl-4-yl]piperazin-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

3.1: potassium carbonate / dimethyl sulfoxide / 1 h / 110 °C / Microwave irradiation

3.2: 16 h / 20 °C

3.3: pH 5

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; dimethyl sulfoxide;

Reference yield:

: 946386-78-3
2-(4-bromo-phenyl)-5-chloro-1H-benzoimidazole

: 1388142-58-2
{4-[4'-(5-chloro-1H-benzimidazol-2-yl)biphenyl-4-yl]piperazin-1-yl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 16 h / 100 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 16 h / 20 °C

3.1: potassium carbonate / dimethyl sulfoxide / 1 h / 110 °C / Microwave irradiation

3.2: 16 h / 20 °C

3.3: pH 5

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; dimethyl sulfoxide;