N-[{3-(N-p-chlorobenzyl-N-methylaminomethyl)phenyl}methyl]formamide

Base Information

• Chemical Name: N-[{3-(N-p-chlorobenzyl-N-methylaminomethyl)phenyl}methyl]formamide
• CAS No.: 1297587-32-6
• Molecular Formula: C₁₇H₁₉ClN₂O
• Molecular Weight: 302.804
• Mol file: 1297587-32-6.mol

Synonyms:N-[{3-(N-p-chlorobenzyl-N-methylaminomethyl)phenyl}methyl]formamide

Chemical Property of N-[{3-(N-p-chlorobenzyl-N-methylaminomethyl)phenyl}methyl]formamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[{3-(N-p-chlorobenzyl-N-methylaminomethyl)phenyl}methyl]formamide

There total 6 articles about N-[{3-(N-p-chlorobenzyl-N-methylaminomethyl)phenyl}methyl]formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

m-[(N-4-chlorobenzyl-N-methyl)aminomethyl]benzylamine (1207535-56-5) + formic acid ethyl ester (109-94-4) → N-[{3-(N-p-chlorobenzyl-N-methylaminomethyl)phenyl}methyl]formamide (1297587-32-6)

Guidance literature:

Inert atmosphere; Reflux;

DOI:10.1016/j.ejmech.2011.02.026

Reference yield:

1-(azidomethyl)-3-(bromomethyl)benzene (1144106-66-0) → N-[{3-(N-p-chlorobenzyl-N-methylaminomethyl)phenyl}methyl]formamide (1297587-32-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 6 h / 0 °C / Reflux

2.1: triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 6 h / Inert atmosphere; Reflux

3.1: Inert atmosphere; Reflux

With potassium carbonate; triphenylphosphine; In tetrahydrofuran; acetonitrile; 2.1: Staudinger reaction / 2.2: Staudinger reaction;

DOI:10.1016/j.ejmech.2011.02.026

Reference yield:

N-[{3-(azidomethyl)phenyl}methyl]-N-(4-chlorobenzyl)methylamine (1207535-55-4) → N-[{3-(N-p-chlorobenzyl-N-methylaminomethyl)phenyl}methyl]formamide (1297587-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triphenylphosphine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

1.2: 6 h / Inert atmosphere; Reflux

2.1: Inert atmosphere; Reflux

With triphenylphosphine; In tetrahydrofuran; 1.1: Staudinger reaction / 1.2: Staudinger reaction;

DOI:10.1016/j.ejmech.2011.02.026

upstream raw materials:

1-(azidomethyl)-3-(bromomethyl)benzene

N-[{3-(azidomethyl)phenyl}methyl]-N-(4-chlorobenzyl)methylamine

m-[(N-4-chlorobenzyl-N-methyl)aminomethyl]benzylamine

formic acid ethyl ester