2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-N-methyl-isobutyramide

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Chemical Name:2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-N-methyl-isobutyramide
CAS No.:311335-69-0
Molecular Formula:C₂₈H₂₈ClF₆N₅O
Molecular Weight:600.007
Hs Code.:

Synonyms:2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-N-methyl-isobutyramide

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Chemical Property of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-N-methyl-isobutyramide

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Technology Process of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-N-methyl-isobutyramide

There total 9 articles about 2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-N-methyl-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 109-01-3
1-methyl-piperazine

: 311335-68-9
2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyl-pyrimidin-4-yl]-N-methyl-isobutyramide

: 311335-69-0
2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-N-methyl-isobutyramide

Guidance literature:: In 1,4-dioxane; for 16h;

Reference yield:

: 3900-89-8
2-Chlorobenzeneboronic acid

: 311335-69-0
2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-N-methyl-isobutyramide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 105 °C

2.1: sodium hydroxide / ethanol / 1 h / 20 °C

2.2: pH 1

3.1: diphenylphosphoranyl azide; triethylamine / tetrahydrofuran / 12 h

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h

4.2: 3 h / 0 °C

5.1: hydrogenchloride / ethanol / 3 h / 55 °C

6.1: potassium hexamethylsilazane / tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide / 1 h / 0 °C

6.2: 24 h / 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 5 - 20 °C

8.1: 1,4-dioxane / 16 h

With hydrogenchloride; sodium hydroxide; diphenylphosphoranyl azide; potassium hexamethylsilazane; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 311335-86-1
[5-(2-Chloro-phenyl)-2-methylsulfanyl-pyrimidin-4-yl]-carbamic acid tert.-butyl ester

: 311335-69-0
2-(3,5-bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-N-methyl-isobutyramide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h

1.2: 3 h / 0 °C

2.1: hydrogenchloride / ethanol / 3 h / 55 °C

3.1: potassium hexamethylsilazane / tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide / 1 h / 0 °C

3.2: 24 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 5 - 20 °C

5.1: 1,4-dioxane / 16 h

With hydrogenchloride; potassium hexamethylsilazane; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;