2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyl-pyrimidin-4-yl]-N-methyl-isobutyramide

Base Information

Chemical Name:2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyl-pyrimidin-4-yl]-N-methyl-isobutyramide
CAS No.:311335-68-9
Molecular Formula:C₂₄H₂₀ClF₆N₃O₃S
Molecular Weight:579.951
Hs Code.:

Synonyms:2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyl-pyrimidin-4-yl]-N-methyl-isobutyramide

Suppliers and Price of 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyl-pyrimidin-4-yl]-N-methyl-isobutyramide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyl-pyrimidin-4-yl]-N-methyl-isobutyramide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyl-pyrimidin-4-yl]-N-methyl-isobutyramide

There total 9 articles about 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyl-pyrimidin-4-yl]-N-methyl-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methylsulfanyl-pyrimidin-4-yl]-N-methyl-isobutyramide

: 311335-68-9
2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyl-pyrimidin-4-yl]-N-methyl-isobutyramide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 5 - 20 ℃; for 3h;

Reference yield:

: 74840-38-3
ethyl 5-bromo-2-methylthio-4-pyrimidinecarboxylate

: 311335-68-9
2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyl-pyrimidin-4-yl]-N-methyl-isobutyramide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 105 °C

2.1: sodium hydroxide / ethanol / 1 h / 20 °C

2.2: pH 1

3.1: diphenylphosphoranyl azide; triethylamine / tetrahydrofuran / 12 h

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h

4.2: 3 h / 0 °C

5.1: hydrogenchloride / ethanol / 3 h / 55 °C

6.1: potassium hexamethylsilazane / tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide / 1 h / 0 °C

6.2: 24 h / 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 5 - 20 °C

With hydrogenchloride; sodium hydroxide; diphenylphosphoranyl azide; potassium hexamethylsilazane; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium diacetate; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 3900-89-8
2-Chlorobenzeneboronic acid

: 311335-68-9
2-(3,5-Bis-trifluoromethyl-phenyl)-N-[5-(2-chloro-phenyl)-2-methanesulfonyl-pyrimidin-4-yl]-N-methyl-isobutyramide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 105 °C

2.1: sodium hydroxide / ethanol / 1 h / 20 °C

2.2: pH 1

3.1: diphenylphosphoranyl azide; triethylamine / tetrahydrofuran / 12 h

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h

4.2: 3 h / 0 °C

5.1: hydrogenchloride / ethanol / 3 h / 55 °C

6.1: potassium hexamethylsilazane / tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide / 1 h / 0 °C

6.2: 24 h / 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 5 - 20 °C

With hydrogenchloride; sodium hydroxide; diphenylphosphoranyl azide; potassium hexamethylsilazane; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium diacetate; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;