(2R)-2-isobutyl-3-oxo-3,6-dihydro-2H-pyran-2-carboxylic acid 2',6'-dimethylphenyl ester

Base Information

Chemical Name:(2R)-2-isobutyl-3-oxo-3,6-dihydro-2H-pyran-2-carboxylic acid 2',6'-dimethylphenyl ester
CAS No.:462118-92-9
Molecular Formula:C₁₈H₂₂O₄
Molecular Weight:302.37
Hs Code.:

Synonyms:(2R)-2-isobutyl-3-oxo-3,6-dihydro-2H-pyran-2-carboxylic acid 2',6'-dimethylphenyl ester

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Chemical Property of (2R)-2-isobutyl-3-oxo-3,6-dihydro-2H-pyran-2-carboxylic acid 2',6'-dimethylphenyl ester

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Technology Process of (2R)-2-isobutyl-3-oxo-3,6-dihydro-2H-pyran-2-carboxylic acid 2',6'-dimethylphenyl ester

There total 8 articles about (2R)-2-isobutyl-3-oxo-3,6-dihydro-2H-pyran-2-carboxylic acid 2',6'-dimethylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-2-Acetyl-4-methyl-2-(2-oxo-ethoxy)-pentanoic acid 2,6-dimethyl-phenyl ester

: 462118-92-9
(2R)-2-isobutyl-3-oxo-3,6-dihydro-2H-pyran-2-carboxylic acid 2',6'-dimethylphenyl ester

Guidance literature:: With (1S)-10-camphorsulfonic acid; In toluene; for 4h; Heating;
DOI:10.1021/ol0263595

Reference yield:

: (2'S)-(2'-hydroxymethyl-pyrrolidin-1'-yl)-(2-isobutyl-3-methyl-2,5-dihydrofuran-2-yl)-methanone

: 462118-92-9
(2R)-2-isobutyl-3-oxo-3,6-dihydro-2H-pyran-2-carboxylic acid 2',6'-dimethylphenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. HCl / 2.5 h / Heating

2.1: 77 percent / EDCl; DMAP / CH₂Cl₂ / 2 h / 20 °C

3.1: ozone / CH₂Cl₂ / 0.5 h

3.2: dimethyl sulfide / CH₂Cl₂ / 16 h

4.1: 170 mg / D (+)-camphor sulfonic acid / toluene / 4 h / Heating

With hydrogenchloride; dmap; (1S)-10-camphorsulfonic acid; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; toluene;
DOI:10.1021/ol0263595

Reference yield:

: 22601-06-5
3-methylfuran-2-carbonyl chloride

: 462118-92-9
(2R)-2-isobutyl-3-oxo-3,6-dihydro-2H-pyran-2-carboxylic acid 2',6'-dimethylphenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaOH / CH₂Cl₂

2.1: NaH; TBAI / tetrahydrofuran

3.1: lithium; ammonia / tetrahydrofuran / 0.5 h / -78 °C

3.2: 98 percent / isoprene / tetrahydrofuran / 1 h

4.1: aq. HCl / 2.5 h / Heating

5.1: 77 percent / EDCl; DMAP / CH₂Cl₂ / 2 h / 20 °C

6.1: ozone / CH₂Cl₂ / 0.5 h

6.2: dimethyl sulfide / CH₂Cl₂ / 16 h

7.1: 170 mg / D (+)-camphor sulfonic acid / toluene / 4 h / Heating

With hydrogenchloride; dmap; sodium hydroxide; (1S)-10-camphorsulfonic acid; ammonia; tetra-(n-butyl)ammonium iodide; lithium; sodium hydride; ozone; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; toluene; 3.1: Birch reduction;
DOI:10.1021/ol0263595