(2S,3S)-S-(N-carbobenzyloxyglycyl)-S'-L-alanyl-2,3-bis(2-mercaptophenylthiomethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane hydrochloride

Base Information

Chemical Name:(2S,3S)-S-(N-carbobenzyloxyglycyl)-S'-L-alanyl-2,3-bis(2-mercaptophenylthiomethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane hydrochloride
CAS No.:125372-66-9
Molecular Formula:C₃₉H₅₀N₂O₁₀S₄*ClH
Molecular Weight:871.558
Hs Code.:

Synonyms:(2S,3S)-S-(N-carbobenzyloxyglycyl)-S'-L-alanyl-2,3-bis(2-mercaptophenylthiomethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane hydrochloride

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Chemical Property of (2S,3S)-S-(N-carbobenzyloxyglycyl)-S'-L-alanyl-2,3-bis(2-mercaptophenylthiomethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane hydrochloride

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Technology Process of (2S,3S)-S-(N-carbobenzyloxyglycyl)-S'-L-alanyl-2,3-bis(2-mercaptophenylthiomethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane hydrochloride

There total 3 articles about (2S,3S)-S-(N-carbobenzyloxyglycyl)-S'-L-alanyl-2,3-bis(2-mercaptophenylthiomethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73893-12-6
(1S,2S)-1,2-Bis-tosyloxymethyl-18-krone-6

: 125372-66-9
(2S,3S)-S-(N-carbobenzyloxyglycyl)-S'-L-alanyl-2,3-bis(2-mercaptophenylthiomethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / 1N aq. KOH / ethanol; tetrahydrofuran / 2 h / 50 °C

2: 1.) Et₃N, 2.) pyridine / 1.) EtOH, room t., 30 min, 2.) acetone, room t., 15 min

With pyridine; potassium hydroxide; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1248/cpb.37.912

Reference yield:

: 17534-15-5
Benzene-1,2-dithiol

: 125372-66-9
(2S,3S)-S-(N-carbobenzyloxyglycyl)-S'-L-alanyl-2,3-bis(2-mercaptophenylthiomethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / 1N aq. KOH / ethanol; tetrahydrofuran / 2 h / 50 °C

2: 1.) Et₃N, 2.) pyridine / 1.) EtOH, room t., 30 min, 2.) acetone, room t., 15 min

With pyridine; potassium hydroxide; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1248/cpb.37.912

Reference yield:

: 1738-86-9
Z-Gly-ONp

: 5673-65-4
L-alanine p-nitrophenyl ester hydrobromide

: 125372-53-4
(+)-(2S,3S)-2,3-bis(2-mercaptophenylthiomethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane

: 125372-64-7
Benzyloxycarbonylamino-thioacetic acid S-(2-{(2R,3R)-3-[2-(2-benzyloxycarbonylamino-acetylsulfanyl)-phenylsulfanylmethyl]-1,4,7,10,13,16-hexaoxa-cyclooctadec-2-ylmethylsulfanyl}-phenyl) ester

: 125372-66-9
(2S,3S)-S-(N-carbobenzyloxyglycyl)-S'-L-alanyl-2,3-bis(2-mercaptophenylthiomethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane hydrochloride

Guidance literature:: With pyridine; triethylamine; Yield given. Multistep reaction. Yields of byproduct given; 1.) EtOH, room t., 30 min, 2.) acetone, room t., 15 min;
DOI:10.1248/cpb.37.912