(S)-2-Benzoylamino-thiopropionic acid S-(2-{(2R,3R)-3-[2-(2-benzyloxycarbonylamino-acetylsulfanyl)-phenylsulfanylmethyl]-1,4,7,10,13,16-hexaoxa-cyclooctadec-2-ylmethylsulfanyl}-phenyl) ester

Base Information

Chemical Name:(S)-2-Benzoylamino-thiopropionic acid S-(2-{(2R,3R)-3-[2-(2-benzyloxycarbonylamino-acetylsulfanyl)-phenylsulfanylmethyl]-1,4,7,10,13,16-hexaoxa-cyclooctadec-2-ylmethylsulfanyl}-phenyl) ester
CAS No.:125372-71-6
Molecular Formula:C₄₆H₅₄N₂O₁₁S₄
Molecular Weight:939.206
Hs Code.:

(S)-2-Benzoylamino-thiopropionic acid S-(2-{(2R,3R)-3-[2-(2-benzyloxycarbonylamino-acetylsulfanyl)-phenylsulfanylmethyl]-1,4,7,10,13,16-hexaoxa-cyclooctadec-2-ylmethylsulfanyl}-phenyl) ester

Synonyms:(S)-2-Benzoylamino-thiopropionic acid S-(2-{(2R,3R)-3-[2-(2-benzyloxycarbonylamino-acetylsulfanyl)-phenylsulfanylmethyl]-1,4,7,10,13,16-hexaoxa-cyclooctadec-2-ylmethylsulfanyl}-phenyl) ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-Benzoylamino-thiopropionic acid S-(2-{(2R,3R)-3-[2-(2-benzyloxycarbonylamino-acetylsulfanyl)-phenylsulfanylmethyl]-1,4,7,10,13,16-hexaoxa-cyclooctadec-2-ylmethylsulfanyl}-phenyl) ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-Benzoylamino-thiopropionic acid S-(2-{(2R,3R)-3-[2-(2-benzyloxycarbonylamino-acetylsulfanyl)-phenylsulfanylmethyl]-1,4,7,10,13,16-hexaoxa-cyclooctadec-2-ylmethylsulfanyl}-phenyl) ester

There total 5 articles about (S)-2-Benzoylamino-thiopropionic acid S-(2-{(2R,3R)-3-[2-(2-benzyloxycarbonylamino-acetylsulfanyl)-phenylsulfanylmethyl]-1,4,7,10,13,16-hexaoxa-cyclooctadec-2-ylmethylsulfanyl}-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 98-88-4
benzoyl chloride

: 125372-66-9
(2S,3S)-S-(N-carbobenzyloxyglycyl)-S'-L-alanyl-2,3-bis(2-mercaptophenylthiomethyl)-1,4,7,10,13,16-hexaoxacyclooctadecane hydrochloride

: 125372-71-6
(S)-2-Benzoylamino-thiopropionic acid S-(2-{(2R,3R)-3-[2-(2-benzyloxycarbonylamino-acetylsulfanyl)-phenylsulfanylmethyl]-1,4,7,10,13,16-hexaoxa-cyclooctadec-2-ylmethylsulfanyl}-phenyl) ester

Guidance literature:: With triethylamine; In chloroform;
DOI:10.1248/cpb.37.912

Reference yield:

: 73893-12-6
(1S,2S)-1,2-Bis-tosyloxymethyl-18-krone-6

: 125372-71-6
(S)-2-Benzoylamino-thiopropionic acid S-(2-{(2R,3R)-3-[2-(2-benzyloxycarbonylamino-acetylsulfanyl)-phenylsulfanylmethyl]-1,4,7,10,13,16-hexaoxa-cyclooctadec-2-ylmethylsulfanyl}-phenyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 43 percent / 1N aq. KOH / ethanol; tetrahydrofuran / 2 h / 50 °C

2: 1.) Et₃N, 2.) pyridine / 1.) EtOH, room t., 30 min, 2.) acetone, room t., 15 min

3: 75 percent / Et₃N / CHCl₃

With pyridine; potassium hydroxide; triethylamine; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1248/cpb.37.912

Reference yield:

: 1738-86-9
Z-Gly-ONp

: 125372-71-6
(S)-2-Benzoylamino-thiopropionic acid S-(2-{(2R,3R)-3-[2-(2-benzyloxycarbonylamino-acetylsulfanyl)-phenylsulfanylmethyl]-1,4,7,10,13,16-hexaoxa-cyclooctadec-2-ylmethylsulfanyl}-phenyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Et₃N, 2.) pyridine / 1.) EtOH, room t., 30 min, 2.) acetone, room t., 15 min

2: 75 percent / Et₃N / CHCl₃

With pyridine; triethylamine; In chloroform;
DOI:10.1248/cpb.37.912