N-[(1R,2R)-2-(2,4-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4-trifluoromethyl-benzamide

Base Information

Chemical Name:N-[(1R,2R)-2-(2,4-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4-trifluoromethyl-benzamide
CAS No.:136926-13-1
Molecular Formula:C₂₀H₁₇F₅N₄O₂
Molecular Weight:440.373
Hs Code.:

Synonyms:N-[(1R,2R)-2-(2,4-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4-trifluoromethyl-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1R,2R)-2-(2,4-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4-trifluoromethyl-benzamide

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Technology Process of N-[(1R,2R)-2-(2,4-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4-trifluoromethyl-benzamide

There total 3 articles about N-[(1R,2R)-2-(2,4-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 127000-91-3
(2R,3R)-3-Amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

: 136926-13-1
N-[(1R,2R)-2-(2,4-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4-trifluoromethyl-benzamide

Guidance literature:: With pyridine; at 0 ℃; for 1h;
DOI:10.1248/cpb.39.2581

Reference yield: 77.0%

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 126916-57-2,127000-91-3,132563-71-4
(2R*,3R*)-3-Amino-2-(2,4-difluoropropyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

: 126916-59-4,136926-13-1,139067-60-0
N-[(1S,2S)-2-(2,4-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4-trifluoromethyl-benzamide

Guidance literature:: With pyridine; at 0 ℃;
DOI:10.1248/cpb.39.2581

Reference yield:

: 126917-48-4
(2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

: 136926-13-1
N-[(1R,2R)-2-(2,4-Difluoro-phenyl)-2-hydroxy-1-methyl-3-[1,2,4]triazol-1-yl-propyl]-4-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / 10percent Pd/C / ethanol / 1 h / 760 Torr

2: 81 percent / pyridine / 1 h / 0 °C

With pyridine; hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1248/cpb.39.2581