(1R,2R,6R,10S)-1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl-oxy)-4-(1,2,6,10-tetramethyldodecyloxymethyl)benzene

Base Information

• Chemical Name: (1R,2R,6R,10S)-1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl-oxy)-4-(1,2,6,10-tetramethyldodecyloxymethyl)benzene
• CAS No.: 780773-21-9
• Molecular Formula: C₃₄H₄₅F₁₇O₂
• Molecular Weight: 808.703
• Mol file: 780773-21-9.mol

Synonyms:(1R,2R,6R,10S)-1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl-oxy)-4-(1,2,6,10-tetramethyldodecyloxymethyl)benzene

Chemical Property of (1R,2R,6R,10S)-1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl-oxy)-4-(1,2,6,10-tetramethyldodecyloxymethyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R,6R,10S)-1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl-oxy)-4-(1,2,6,10-tetramethyldodecyloxymethyl)benzene

There total 23 articles about (1R,2R,6R,10S)-1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl-oxy)-4-(1,2,6,10-tetramethyldodecyloxymethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-Heptadecafluoro-undecyloxy)-4-((3E,7E)-(1R,2R,6S,10R)-1,2,6,10-tetramethyl-dodeca-3,7,11-trienyloxymethyl)-benzene (780772-91-0) → (1R,2R,6R,10S)-1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl-oxy)-4-(1,2,6,10-tetramethyldodecyloxymethyl)benzene (780773-21-9)

Guidance literature:

With copper(I) sulfate; copper(II) sulfate; hydrazine; In ethanol; at 70 ℃; for 20h;

DOI:10.1021/jo051526a

Reference yield:

5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butylsulfanyl]-1-phenyl-1H-tetrazole → (1R,2R,6R,10S)-1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl-oxy)-4-(1,2,6,10-tetramethyldodecyloxymethyl)benzene (780773-21-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 5.28 g / hydrogen peroxide / (NH₄)6Mo₇O₂₄*4H₂O / tetrahydrofuran; ethanol / 14 h / 20 °C

2.1: sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -78 °C

2.2: tetrahydrofuran / 2 h / -78 °C

3.1: TBAF / tetrahydrofuran / 3 h / 20 °C

4.1: Dess-Martin periodinane / CH₂Cl₂ / 3 h / 20 °C

5.1: sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -78 °C

5.2: tetrahydrofuran / 5 h / -78 - 20 °C

6.1: 117 mg / hydrazine; copper sulfate / ethanol / 20 h / 70 °C

With copper(I) sulfate; tetrabutyl ammonium fluoride; dihydrogen peroxide; sodium hexamethyldisilazane; Dess-Martin periodane; copper(II) sulfate; hydrazine; ammonium heptamolybdate; In tetrahydrofuran; ethanol; dichloromethane; 2.2: Kocienski-Julia olefination / 4.1: Dess-Martin oxidation / 5.2: Wittig reaction;

DOI:10.1021/jo051526a

Reference yield:

5-[4-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butylsulfanyl]-1-phenyl-1H-tetrazole → (1R,2R,6R,10S)-1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl-oxy)-4-(1,2,6,10-tetramethyldodecyloxymethyl)benzene (780773-21-9)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 3.76 g / hydrogen peroxide / (NH₄)6Mo₇O₂₄*4H₂O / tetrahydrofuran; ethanol / 14 h / 20 °C

2.1: sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -78 °C

2.2: tetrahydrofuran / 2 h / -78 °C

3.1: TBAF / tetrahydrofuran / 3 h / 20 °C

4.1: Dess-Martin periodinane / CH₂Cl₂ / 3 h / 20 °C

5.1: sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -78 °C

5.2: tetrahydrofuran / 2 h / -78 °C

6.1: TBAF / tetrahydrofuran / 3 h / 20 °C

7.1: Dess-Martin periodinane / CH₂Cl₂ / 3 h / 20 °C

8.1: sodium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -78 °C

8.2: tetrahydrofuran / 5 h / -78 - 20 °C

9.1: 117 mg / hydrazine; copper sulfate / ethanol / 20 h / 70 °C

With copper(I) sulfate; tetrabutyl ammonium fluoride; dihydrogen peroxide; sodium hexamethyldisilazane; Dess-Martin periodane; copper(II) sulfate; hydrazine; ammonium heptamolybdate; In tetrahydrofuran; ethanol; dichloromethane; 2.2: Kocienski-Julia olefination / 4.1: Dess-Martin oxidation / 5.2: Kocienski-Julia olefination / 7.1: Dess-Martin oxidation / 8.2: Wittig reaction;

DOI:10.1021/jo051526a

upstream raw materials:

1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-Heptadecafluoro-undecyloxy)-4-((3E,7E)-(1R,2R,6S,10R)-1,2,6,10-tetramethyl-dodeca-3,7,11-trienyloxymethyl)-benzene

4-nitrobenzoic acid (1R,2S)-2-ethoxycarbonyl-1-methylpropyl ester

(3S)-5-[4-(tert-butyldimethylsilanyloxy)-3-methylbutane-1-sulfonyl]-1-phenyl-1H-tetrazole

(3R)-5-[4-(tert-butyldimethylsilanyloxy)-3-methylbutane-1-sulfonyl]-1-phenyl-1H-tetrazole