1-[(8-bromo-4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylic acid

Base Information

• Chemical Name: 1-[(8-bromo-4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylic acid
• CAS No.: 1169551-09-0
• Molecular Formula: C₁₆H₁₄BrN₃O₄
• Molecular Weight: 392.209

Synonyms:1-[(8-bromo-4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylic acid

Chemical Property of 1-[(8-bromo-4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylic acid

Chemical Property:

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Technology Process of 1-[(8-bromo-4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylic acid

There total 1 articles about 1-[(8-bromo-4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrrolidine-3-carboxylic acid (59378-87-9,68464-02-8,72580-53-1,72580-54-2) + 5-bromo-3-(2-chloroacetamido)benzofuran-2-carboxamide (1169559-16-3) → 1-[(8-bromo-4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylic acid (1169551-09-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 85 °C

2: sodium hydroxide / ethanol / 85 °C

With sodium hydroxide; In ethanol;

DOI:10.1016/j.bmcl.2012.04.024

Reference yield: 17.0%

1-[(8-bromo-4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-2-yl)methyl]pyrrolidine-3-carboxylic acid (1169551-09-0) + 2-CHLOROBENZYLAMINE (89-97-4) → 1-[(8-bromo-4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-2-yl)methyl]-N-[(2-chlorophenyl)methyl]pyrrolidine-3-carboxamide (1169553-46-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In ISOPROPYLAMIDE; at 20 ℃; for 2h;

upstream raw materials:

pyrrolidine-3-carboxylic acid

5-bromo-3-(2-chloroacetamido)benzofuran-2-carboxamide

Downstream raw materials:

1-[(8-bromo-4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-2-yl)methyl]-N-[(2-chlorophenyl)methyl]pyrrolidine-3-carboxamide

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