(R)-2-Formyl-1-<(3-hydroxy-4-methoxyphenyl)methyl>-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(R)-2-Formyl-1-<(3-hydroxy-4-methoxyphenyl)methyl>-6-methoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:154013-19-1
Molecular Formula:C₁₉H₂₁NO₄
Molecular Weight:327.38
Hs Code.:

Synonyms:(R)-2-Formyl-1-<(3-hydroxy-4-methoxyphenyl)methyl>-6-methoxy-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (R)-2-Formyl-1-<(3-hydroxy-4-methoxyphenyl)methyl>-6-methoxy-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (R)-2-Formyl-1-<(3-hydroxy-4-methoxyphenyl)methyl>-6-methoxy-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about (R)-2-Formyl-1-<(3-hydroxy-4-methoxyphenyl)methyl>-6-methoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 154013-12-4
(Z)-2-Formyl-1-<(3-hydroxy-4-methoxyphenyl)methylene>-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: (S)-2-Formyl-1-<(3-hydroxy-4-methoxyphenyl)methyl>-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 154013-19-1
(R)-2-Formyl-1-<(3-hydroxy-4-methoxyphenyl)methyl>-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With hydrogen; Ru<(R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl>(OCOCH3)2; In methanol; dichloromethane; at 25 ℃; for 98h; under 38000 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00081a007

Reference yield:

: 95427-40-0
1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline

: 154013-19-1
(R)-2-Formyl-1-<(3-hydroxy-4-methoxyphenyl)methyl>-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 12 h / Ambient temperature

2: 28percent aq. NH₄OH

3: H₂ / Ru(CH₃COO)2<(R)-BINAP> / methanol; CH₂Cl₂ / 98 h / 25 °C / 38000 Torr

With pyridine; ammonium hydroxide; hydrogen; Ru<(R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl>(OCOCH3)2; In methanol; dichloromethane;
DOI:10.1021/jo00081a007

Reference yield:

: Formic acid 5-[2-formyl-6-methoxy-3,4-dihydro-2H-isoquinolin-(1Z)-ylidenemethyl]-2-methoxy-phenyl ester

: 154013-19-1
(R)-2-Formyl-1-<(3-hydroxy-4-methoxyphenyl)methyl>-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 28percent aq. NH₄OH

2: H₂ / Ru(CH₃COO)2<(R)-BINAP> / methanol; CH₂Cl₂ / 98 h / 25 °C / 38000 Torr

With ammonium hydroxide; hydrogen; Ru<(R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl>(OCOCH3)2; In methanol; dichloromethane;
DOI:10.1021/jo00081a007