95427-40-0

Basic information

• Product Name: 1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline
• Synonyms: 1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline
• CAS NO: 95427-40-0
• Molecular Weight: 297.354
• Mol File: 95427-40-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline(95427-40-0)
• EPA Substance Registry System: 1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-3,4-dihydroisoquinoline(95427-40-0)

Safety Data

• Hazardous Substances Data: 95427-40-0(Hazardous Substances Data)

Upstream product

• 74007-21-9 N-<2-(3-methoxyphenyl)ethyl>(3-hydroxy-4-methoxyphenyl)acetamide 
• 1033384-84-7 C₁₈H₁₉NO₃*H₃O₄P 
• 1131-94-8 homoisovanillic acid 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 1033384-75-6 C₁₈H₁₈NO₃^(1-)*Na⁽¹⁺⁾ 

Downstream Products

• 74035-73-7 (+)-(R)-1-(3-hydroxy-4-methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 1033440-28-6 CH₂O₂*C₁₈H₂₁NO₃ 
• 74035-74-8 2-Methoxy-5-((S)-6-methoxy-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenol 
• 154013-19-1 (R)-2-Formyl-1-<(3-hydroxy-4-methoxyphenyl)methyl>-6-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 154013-12-4 (Z)-2-Formyl-1-<(3-hydroxy-4-methoxyphenyl)methylene>-6-methoxy-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

PREPARATION OF 3,4-DIHYDROISOQUINOLINES FROM AN ACID AND AN AMINE

The present invention is directed to processes for the synthesis of morphinans. In particular, a process for coupling a carboxylic acid compound with an amine compound to form an amide product that can then be isolated or the crude amide product can be cy

Chemistry of opium alkaloids, 45. Improvements in the total synthesis of morphine

The chiral 1,2,3,4-tetrahydroisoquinoline intermediates in the Price and Beyerman routes to morphine, (+)-(R)-1-(3-hydroxy-4-methoxybenzyl)-6-methoxy- 1,2,3,4-tetrahydroisoquinoline (6) and (+)-(R)-1-(3,5-dibenzyloxy-4- methoxybenzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline (5), were prepared in high ee by ruthenium-catalyzed asymmetric transfer hydrogenation of the corresponding imine precursors (Noyori method). The yield of the key raw material in the Beyerman route, 3,5-dibenzyloxy-4-methoxyphenylacetric acid (1), starting from gallic acid methyl ester (7) was improved by a factor of 5 over previously described syntheses. Key steps in the new procedure are the selective formation of methyl 3,5-dihydroxy-4-methoxybenzoate (9) via the 3,5-diacetate and an improved benzylation of the hydroxyl groups in 9.