(S)-3-(8,8-dioxo-5-oxa-8λ⁶-thia-7-azaspiro[3.5]non-6-en-6-ylamino)-3-phenylpropan-1-ol

Base Information

• Chemical Name: (S)-3-(8,8-dioxo-5-oxa-8λ⁶-thia-7-azaspiro[3.5]non-6-en-6-ylamino)-3-phenylpropan-1-ol
• CAS No.: 1397342-35-6
• Molecular Formula: C₁₅H₂₀N₂O₄S
• Molecular Weight: 324.401

Synonyms:(S)-3-(8,8-dioxo-5-oxa-8λ⁶-thia-7-azaspiro[3.5]non-6-en-6-ylamino)-3-phenylpropan-1-ol

Chemical Property of (S)-3-(8,8-dioxo-5-oxa-8λ⁶-thia-7-azaspiro[3.5]non-6-en-6-ylamino)-3-phenylpropan-1-ol

Chemical Property:

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Technology Process of (S)-3-(8,8-dioxo-5-oxa-8λ⁶-thia-7-azaspiro[3.5]non-6-en-6-ylamino)-3-phenylpropan-1-ol

There total 4 articles about (S)-3-(8,8-dioxo-5-oxa-8λ⁶-thia-7-azaspiro[3.5]non-6-en-6-ylamino)-3-phenylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-amino-O-tert-butyldimethylsilyl-3-phenylpropan-1-ol + (1-hydroxycyclobutyl)methanesulfonamide (1397401-52-3) + 1,1'-Thiocarbonyldiimidazole (6160-65-2) → (S)-3-(8,8-dioxo-5-oxa-8λ6-thia-7-azaspiro[3.5]non-6-en-6-ylamino)-3-phenylpropan-1-ol (1397342-35-6)

Guidance literature:

(S)-3-amino-O-tert-butyldimethylsilyl-3-phenylpropan-1-ol; 1,1'-Thiocarbonyldiimidazole; In dichloromethane; for 0.333333h;

(1-hydroxycyclobutyl)methanesulfonamide; With sodium hexamethyldisilazane; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at -10 ℃; for 0.0833333h; Further stages; Inert atmosphere;

Reference yield:

(S)-3-amino-O-tert-butyldimethylsilyl-3-phenylpropan-1-ol + (1-hydroxycyclobutyl)methanesulfonamide (1397401-52-3) → (S)-3-(8,8-dioxo-5-oxa-8λ6-thia-7-azaspiro[3.5]non-6-en-6-ylamino)-3-phenylpropan-1-ol (1397342-35-6)

Guidance literature:

(S)-3-amino-O-tert-butyldimethylsilyl-3-phenylpropan-1-ol; With 1,1'-Thiocarbonyldiimidazole; In dichloromethane; for 0.333333h; Inert atmosphere;

(1-hydroxycyclobutyl)methanesulfonamide; With sodium hexamethyldisilazane; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; at -10 ℃; for 0.583333h; Further stages; Inert atmosphere;

Reference yield:

(S)-3-amino-3-phenyl-1-propanol hydrochloride (936499-93-3,936499-92-2) → (S)-3-(8,8-dioxo-5-oxa-8λ6-thia-7-azaspiro[3.5]non-6-en-6-ylamino)-3-phenylpropan-1-ol (1397342-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 3 h / 20 °C

2.1: dichloromethane / 0.33 h

2.2: 0.58 h / -10 °C

With triethylamine; In dichloromethane;

upstream raw materials:

(1-hydroxycyclobutyl)methanesulfonamide

1,1'-Thiocarbonyldiimidazole

(S)-3-amino-3-phenyl-1-propanol hydrochloride

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