N-[(1S)-1-({[(3R)-3-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]amino}carbonyl)-3-methylbutyl]-1-benzothiophene-2-carboxamide

Base Information

Chemical Name:N-[(1S)-1-({[(3R)-3-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]amino}carbonyl)-3-methylbutyl]-1-benzothiophene-2-carboxamide
CAS No.:878799-31-6
Molecular Formula:C₃₃H₃₂ClFN₄O₆S₂
Molecular Weight:699.224
Hs Code.:

N-[(1S)-1-({[(3R)-3-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]amino}carbonyl)-3-methylbutyl]-1-benzothiophene-2-carboxamide

Synonyms:N-[(1S)-1-({[(3R)-3-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]amino}carbonyl)-3-methylbutyl]-1-benzothiophene-2-carboxamide

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Chemical Property of N-[(1S)-1-({[(3R)-3-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]amino}carbonyl)-3-methylbutyl]-1-benzothiophene-2-carboxamide

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Technology Process of N-[(1S)-1-({[(3R)-3-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]amino}carbonyl)-3-methylbutyl]-1-benzothiophene-2-carboxamide

There total 1 articles about N-[(1S)-1-({[(3R)-3-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]amino}carbonyl)-3-methylbutyl]-1-benzothiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 878799-30-5
phenylmethyl {(1R)-3-{[N-(1-benzothien-2-ylcarbonyl)-L-leucyl]amino}-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]propyl}carbamate

: 85958-57-2
2-chloro-4-fluorobenzene-1-sulfonyl chloride

: 878799-31-6
N-[(1S)-1-({[(3R)-3-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]amino}carbonyl)-3-methylbutyl]-1-benzothiophene-2-carboxamide

Guidance literature:: phenylmethyl {(1R)-3-{[N-(1-benzothien-2-ylcarbonyl)-L-leucyl]amino}-1-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]propyl}carbamate; With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 2h;

2-chloro-4-fluorobenzene-1-sulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 67.0%

: 878799-31-6
N-[(1S)-1-({[(3R)-3-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]amino}carbonyl)-3-methylbutyl]-1-benzothiophene-2-carboxamide

: 108-24-7
acetic anhydride

: N-((1S)-1-{[((3R)-4-(acetylamino)-3-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}butyl)amino]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide

Guidance literature:: N-[(1S)-1-({[(3R)-3-{[(2-chloro-4-fluorophenyl)sulfonyl]amino}-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]amino}carbonyl)-3-methylbutyl]-1-benzothiophene-2-carboxamide; With hydrazine; In ethanol; at 20 ℃; for 2h;

acetic anhydride; With triethylamine; In dichloromethane; at 20 ℃;