5-(3-(pyren-1-yl)propoxy)-α,α’-bis((di-2-picolyl)amino)-m-xylene

Base Information

• Chemical Name: 5-(3-(pyren-1-yl)propoxy)-α,α’-bis((di-2-picolyl)amino)-m-xylene
• CAS No.: 1006866-48-3
• Molecular Formula: C₅₁H₄₆N₆O
• Molecular Weight: 758.966
• Mol file: 1006866-48-3.mol

Synonyms:5-(3-(pyren-1-yl)propoxy)-α,α’-bis((di-2-picolyl)amino)-m-xylene

Chemical Property of 5-(3-(pyren-1-yl)propoxy)-α,α’-bis((di-2-picolyl)amino)-m-xylene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3-(pyren-1-yl)propoxy)-α,α’-bis((di-2-picolyl)amino)-m-xylene

There total 9 articles about 5-(3-(pyren-1-yl)propoxy)-α,α’-bis((di-2-picolyl)amino)-m-xylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-(3-(pyren-1-yl)propoxy)-α,α’-dibromo-m-xylene (1006866-47-2) + bis[(2-pyridyl)methyl]amine (1539-42-0) → 5-(3-(pyren-1-yl)propoxy)-α,α’-bis((di-2-picolyl)amino)-m-xylene (1006866-48-3)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 11h;

DOI:10.1021/ja0759139

Reference yield:

3-(pyren-1-yl)acrylic acid (91816-89-6) → 5-(3-(pyren-1-yl)propoxy)-α,α’-bis((di-2-picolyl)amino)-m-xylene (1006866-48-3)

Guidance literature:

Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; isopropyl alcohol

2: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 3.08 h / -78 °C / Reflux

4: lithium aluminium tetrahydride / tetrahydrofuran / 5 h

5: phosphorus tribromide / tetrahydrofuran; dichloromethane / 3 h / 7 °C / Inert atmosphere

6: potassium iodide; potassium carbonate / acetonitrile / 16 h

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; phosphorus tribromide; potassium carbonate; triphenylphosphine; potassium iodide; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetonitrile; 3: |Mitsunobu Displacement;

DOI:10.1021/ol303403x

Reference yield:

{5-[3-(pyren-1-yl)propoxy]-1,3-phenylene}dimethanol (1006866-46-1) → 5-(3-(pyren-1-yl)propoxy)-α,α’-bis((di-2-picolyl)amino)-m-xylene (1006866-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus tribromide / tetrahydrofuran; dichloromethane / 3 h / 7 °C / Inert atmosphere

2: potassium iodide; potassium carbonate / acetonitrile / 16 h

With phosphorus tribromide; potassium carbonate; potassium iodide; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1021/ol303403x

upstream raw materials:

5-(3-(pyren-1-yl)propoxy)-α,α’-dibromo-m-xylene

bis[(2-pyridyl)methyl]amine

3-(1-pyrenyl)propionic acid

{5-[3-(pyren-1-yl)propoxy]-1,3-phenylene}dimethanol