1006866-47-2

Basic information

• Product Name: 5-(3-(pyren-1-yl)propoxy)-α,α’-dibromo-m-xylene
• Synonyms: 5-(3-(pyren-1-yl)propoxy)-α,α’-dibromo-m-xylene
• CAS NO: 1006866-47-2
• Molecular Weight: 522.279
• Mol File: 1006866-47-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(3-(pyren-1-yl)propoxy)-α,α’-dibromo-m-xylene(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-(pyren-1-yl)propoxy)-α,α’-dibromo-m-xylene(1006866-47-2)
• EPA Substance Registry System: 5-(3-(pyren-1-yl)propoxy)-α,α’-dibromo-m-xylene(1006866-47-2)

Safety Data

• Hazardous Substances Data: 1006866-47-2(Hazardous Substances Data)

Upstream product

• 1392406-87-9 3-(pyren-1-yl)prop-2-yn-1-ol 
• 13036-02-7 Dimethyl 5-hydroxyisophthalate 
• 1714-29-0 1-bromopyrene 
• 153707-56-3 3,5-bis(hydroxymethyl)phenol 
• 1006866-45-0 dimethyl 5-(3-(pyren-1-yl)propoxy)isophthalate 
• 91816-89-6 3-(pyren-1-yl)acrylic acid 
• 3029-19-4 pyrene-1-aldehyde 
• 61098-93-9 3-(1-pyrenyl)propionic acid 
• 1006866-46-1 {5-[3-(pyren-1-yl)propoxy]-1,3-phenylene}dimethanol 

Downstream Products

• 1006866-48-3 5-(3-(pyren-1-yl)propoxy)-α,α’-bis((di-2-picolyl)amino)-m-xylene 

Relevant articles and documents

Optimised synthesis of the bacterial magic spot (P)ppGpp chemosensor pyDPA

Guanosine penta-or tetraphosphate (pppGpp or ppGpp, re-spectively) is a nucleotide signalling molecule with a marked effect on bacterial physiology during stress. Its accumulation slows down cell metabolism and replication, supposedly leading to the formation of the antibiotic-tolerant persister phenotype. A specifically tailored fluorescent chemosensor, PyDPA, allows the detection of (p)ppGpp in solution with high selectivity, relative to that of other nucleotides. Herein, an optimised synthetic approach is presented that improves the overall yield from 9 to 67 % over 7 steps. The simplicity and robustness of this approach will allow groups investigating the many facets of (p)ppGpp easy access to this probe.

Selective fluorescent chemosensor for the bacterial alarmone (p)ppGpp

We have developed the first selective fluorescent chemosensor (PyDPA) for (p)ppGpp, a bacterial and plant alarmone. By using pyrene-excimer fluorescence, PyDPA shows very good selectivity for (p)ppGpp from among other nucleotides in water. PyDPA was used