Dimethyl 1-hydroxy-5,6,7-trimethoxy-4-(3,4,5-trimethoxyphenyl)naphthalene-2,3-dicarboxylate

Base Information

Chemical Name:Dimethyl 1-hydroxy-5,6,7-trimethoxy-4-(3,4,5-trimethoxyphenyl)naphthalene-2,3-dicarboxylate
CAS No.:87850-41-7
Molecular Formula:C₂₆H₂₈O₁₁
Molecular Weight:516.502
Hs Code.:
DSSTox Substance ID:DTXSID201334062

Synonyms:SCHEMBL8683213;DTXSID201334062;Dimethyl 1-hydroxy-5,6,7-trimethoxy-4-(3,4,5-trimethoxyphenyl)naphthalene-2,3-dicarboxylate;87850-41-7

Suppliers and Price of Dimethyl 1-hydroxy-5,6,7-trimethoxy-4-(3,4,5-trimethoxyphenyl)naphthalene-2,3-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Dimethyl 1-hydroxy-5,6,7-trimethoxy-4-(3,4,5-trimethoxyphenyl)naphthalene-2,3-dicarboxylate

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:11
Exact Mass:516.16316171
Heavy Atom Count:37
Complexity:749

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=CC(=C1OC)OC)C2=C(C(=C(C3=CC(=C(C(=C32)OC)OC)OC)O)C(=O)OC)C(=O)OC

Technology Process of Dimethyl 1-hydroxy-5,6,7-trimethoxy-4-(3,4,5-trimethoxyphenyl)naphthalene-2,3-dicarboxylate

There total 3 articles about Dimethyl 1-hydroxy-5,6,7-trimethoxy-4-(3,4,5-trimethoxyphenyl)naphthalene-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 87850-24-6
(6-Dimethoxymethyl-2,3,4-trimethoxy-phenyl)-(3,4,5-trimethoxy-phenyl)-methanol

: 762-42-5
dimethyl acetylenedicarboxylate

: 87850-41-7
2,3-bis(methoxycarbonyl)-4-hydroxy-6,7,8-trimethoxy-1-(3,4,5-trimethoxyphenyl)naphthalene

Guidance literature:: With acetic acid; at 130 ℃; for 0.333333h;

Reference yield:

: 87850-44-0
2-bromo-3,4,5-trimethoxybenzaldehydedimethyl acetal

: 87850-41-7
2,3-bis(methoxycarbonyl)-4-hydroxy-6,7,8-trimethoxy-1-(3,4,5-trimethoxyphenyl)naphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) BuLi / 1.) hexane, THF, -70 deg C, 15 min, 2.) hexane, THF, -70 deg C, 15 min

2: 51 percent / p-TsOH*H₂O / benzene / 2 h / Heating

With n-butyllithium; toluene-4-sulfonic acid; In benzene;
DOI:10.1248/cpb.43.1701

Reference yield:

: 35274-53-4
2-bromo-3,4,5-tri-methoxybenzaldehyde

: 87850-41-7
2,3-bis(methoxycarbonyl)-4-hydroxy-6,7,8-trimethoxy-1-(3,4,5-trimethoxyphenyl)naphthalene

Guidance literature:: Multi-step reaction with 3 steps

1: Dowex 50W-X₈ acid exchange resin / methanol / 20 h / Heating

2: 95.6 percent / 1.) n-BuLi / diethyl ether

3: 73 percent / acetic acid / 0.33 h / 130 °C

With n-butyllithium; Dowex 50W-X₈ acid exchange resin; acetic acid; In methanol; diethyl ether;