(E)-3-(4-chlorophenyl)-2-[(2-formyl-3-methyl-1H-indol-1-yl)methyl]prop-2-enoic acid

Base Information

Chemical Name:(E)-3-(4-chlorophenyl)-2-[(2-formyl-3-methyl-1H-indol-1-yl)methyl]prop-2-enoic acid
CAS No.:1335284-67-7
Molecular Formula:C₂₀H₁₆ClNO₃
Molecular Weight:353.805
Hs Code.:

Synonyms:(E)-3-(4-chlorophenyl)-2-[(2-formyl-3-methyl-1H-indol-1-yl)methyl]prop-2-enoic acid

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Chemical Property of (E)-3-(4-chlorophenyl)-2-[(2-formyl-3-methyl-1H-indol-1-yl)methyl]prop-2-enoic acid

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Technology Process of (E)-3-(4-chlorophenyl)-2-[(2-formyl-3-methyl-1H-indol-1-yl)methyl]prop-2-enoic acid

There total 1 articles about (E)-3-(4-chlorophenyl)-2-[(2-formyl-3-methyl-1H-indol-1-yl)methyl]prop-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1232565-80-8
C₂₁H₁₈ClNO₃

: 1335284-67-7
(E)-3-(4-chlorophenyl)-2-[(2-formyl-3-methyl-1H-indol-1-yl)methyl]prop-2-enoic acid

Guidance literature:: C₂₁H₁₈ClNO₃; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 8h;

With hydrogenchloride; In tetrahydrofuran; water;
DOI:10.1016/j.tet.2011.07.074

Reference yield:

: 1335284-67-7
(E)-3-(4-chlorophenyl)-2-[(2-formyl-3-methyl-1H-indol-1-yl)methyl]prop-2-enoic acid

: 541-41-3
chloroformic acid ethyl ester

: C₂₃H₂₀ClNO₅

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; at -10 ℃; for 0.0833333h;
DOI:10.1016/j.tet.2011.07.074

Reference yield:

: 1335284-67-7
(E)-3-(4-chlorophenyl)-2-[(2-formyl-3-methyl-1H-indol-1-yl)methyl]prop-2-enoic acid

: C₂₀H₁₅ClN₄O₂

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine / tetrahydrofuran / 0.08 h / -10 °C

2: sodium azide / tetrahydrofuran; water / 0.5 h / -10 - 20 °C

With 4-methyl-morpholine; sodium azide; In tetrahydrofuran; water;
DOI:10.1016/j.tet.2011.07.074