Technology Process of 2-(benzo[d][1,3]dioxol-5-yl)-N-(3,4-dibromobenzyl)pyrimidin-4-amine
There total 2 articles about 2-(benzo[d][1,3]dioxol-5-yl)-N-(3,4-dibromobenzyl)pyrimidin-4-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(benzo[d][1,3]dioxol-5-yl)pyrimidin-4-amine; 3,4-dibromobenzaldehyde;
With
triisopropoxytitanium(IV) chloride; acetic acid;
In
acetonitrile;
for 0.0833333h;
Combinatorial reaction / High throughput screening (HTS);
With
sodium tris(acetoxy)borohydride;
In
acetonitrile;
for 1.5h;
Combinatorial reaction / High throughput screening (HTS);
DOI:10.1016/j.bmcl.2013.02.096
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane; water / 1 h / 110 °C / Microwave irradiation
2.1: triisopropoxytitanium(IV) chloride; acetic acid / acetonitrile / 0.08 h / Combinatorial reaction / High throughput screening (HTS)
2.2: 1.5 h / Combinatorial reaction / High throughput screening (HTS)
With
triisopropoxytitanium(IV) chloride; tetrakis(triphenylphosphine) palladium(0); sodium carbonate; acetic acid;
In
1,4-dioxane; water; acetonitrile;
1.1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2013.02.096