tert-butyl (1-(4-(1,3-bis(2-fluoroethyl)-2-oxo-7-phenyl-1,2,3,4-tetrahydropyrido[3,2-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Base Information

Chemical Name:tert-butyl (1-(4-(1,3-bis(2-fluoroethyl)-2-oxo-7-phenyl-1,2,3,4-tetrahydropyrido[3,2-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate
CAS No.:1313441-28-9
Molecular Formula:C₃₂H₃₆F₂N₄O₃
Molecular Weight:562.66
Hs Code.:

Synonyms:tert-butyl (1-(4-(1,3-bis(2-fluoroethyl)-2-oxo-7-phenyl-1,2,3,4-tetrahydropyrido[3,2-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

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Chemical Property of tert-butyl (1-(4-(1,3-bis(2-fluoroethyl)-2-oxo-7-phenyl-1,2,3,4-tetrahydropyrido[3,2-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

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Technology Process of tert-butyl (1-(4-(1,3-bis(2-fluoroethyl)-2-oxo-7-phenyl-1,2,3,4-tetrahydropyrido[3,2-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

There total 4 articles about tert-butyl (1-(4-(1,3-bis(2-fluoroethyl)-2-oxo-7-phenyl-1,2,3,4-tetrahydropyrido[3,2-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 762-51-6
1-fluoro-2-iodoethane

: 1313440-98-0
tert-butyl (1-(4-(2-oxo-7-phenyl-1,2,3,4-tetrahydropyrido[3,2-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

: 1313441-28-9
tert-butyl (1-(4-(1,3-bis(2-fluoroethyl)-2-oxo-7-phenyl-1,2,3,4-tetrahydropyrido[3,2-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1313440-75-3
tert-butyl (1-(4-(6-chloro-5-nitro-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate

: 1313441-28-9
tert-butyl (1-(4-(1,3-bis(2-fluoroethyl)-2-oxo-7-phenyl-1,2,3,4-tetrahydropyrido[3,2-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 °C

2: hydrogen / ethanol / 20 °C / 1125.11 Torr / Inert atmosphere

3: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

4: sodium hydride / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With potassium tert-butylate; hydrogen; sodium hydride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1313440-97-9
tert-butyl (1-(4-(5-amino-6-(aminomethyl)-3-phenylpyridin-2-yl)phenyl)cyclobutyl)carbamate

: 1313441-28-9
tert-butyl (1-(4-(1,3-bis(2-fluoroethyl)-2-oxo-7-phenyl-1,2,3,4-tetrahydropyrido[3,2-d]pyrimidin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With sodium hydride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; N,N-dimethyl-formamide;