6-(1-cyclohexylhydrazino)-9-[(4-methyl-1-piperazinyl)carbonyl]-9H-purine-2-carbonitrile

Base Information

Chemical Name:6-(1-cyclohexylhydrazino)-9-[(4-methyl-1-piperazinyl)carbonyl]-9H-purine-2-carbonitrile
CAS No.:1055927-38-2
Molecular Formula:C₁₈H₂₅N₉O
Molecular Weight:383.456
Hs Code.:

Synonyms:6-(1-cyclohexylhydrazino)-9-[(4-methyl-1-piperazinyl)carbonyl]-9H-purine-2-carbonitrile

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Chemical Property of 6-(1-cyclohexylhydrazino)-9-[(4-methyl-1-piperazinyl)carbonyl]-9H-purine-2-carbonitrile

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Technology Process of 6-(1-cyclohexylhydrazino)-9-[(4-methyl-1-piperazinyl)carbonyl]-9H-purine-2-carbonitrile

There total 6 articles about 6-(1-cyclohexylhydrazino)-9-[(4-methyl-1-piperazinyl)carbonyl]-9H-purine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1055925-72-8
1,1-dimethylethyl 2-{2-cyano-9-[(4-methyl-1-piperazinyl)carbonyl]-9H-purin-6-yl}-2-cyclohexylhydrazinecarboxylate trifluoroacetate

: 1055927-38-2
6-(1-cyclohexylhydrazino)-9-[(4-methyl-1-piperazinyl)carbonyl]-9H-purine-2-carbonitrile

Guidance literature:: 1,1-dimethylethyl 2-{2-cyano-9-[(4-methyl-1-piperazinyl)carbonyl]-9H-purin-6-yl}-2-cyclohexylhydrazinecarboxylate trifluoroacetate; With toluene-4-sulfonic acid; In water; acetonitrile; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 1055927-13-3
1,1-dimethylethyl 2-[2-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl]-2-cyclohexylhydrazinecarboxylate

: 1055927-38-2
6-(1-cyclohexylhydrazino)-9-[(4-methyl-1-piperazinyl)carbonyl]-9H-purine-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; zinc / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ISOPROPYLAMIDE / 3 h / 150 °C

2: Dowex 50x2-200 resin / ethanol / 26 h / 20 °C / Heating / reflux

3: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 40 °C

4: water; acetonitrile

5: toluene-4-sulfonic acid / water; acetonitrile / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; Dowex 50x2-200 resin; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 55112-42-0
4-methylpiperazine-1-carbonyl chloride monohydrochloride

: 1055927-38-2
6-(1-cyclohexylhydrazino)-9-[(4-methyl-1-piperazinyl)carbonyl]-9H-purine-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 40 °C

2: water; acetonitrile

3: toluene-4-sulfonic acid / water; acetonitrile / 20 °C

With potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide; acetonitrile;