(+)-(E,S_S,2S,3R)-5-[N-methyl-S-phenylsulfonimidoyl]-3-phenyl-2-[(2-methylprop-2-yl-sulfonyl)-prop-2-ynyl-amino]pent-4-enoic acid ethyl ester

Base Information

• Chemical Name: (+)-(E,S_S,2S,3R)-5-[N-methyl-S-phenylsulfonimidoyl]-3-phenyl-2-[(2-methylprop-2-yl-sulfonyl)-prop-2-ynyl-amino]pent-4-enoic acid ethyl ester
• CAS No.: 616234-13-0
• Molecular Formula: C₂₇H₃₄N₂O₅S₂
• Molecular Weight: 530.709

Synonyms:(+)-(E,S_S,2S,3R)-5-[N-methyl-S-phenylsulfonimidoyl]-3-phenyl-2-[(2-methylprop-2-yl-sulfonyl)-prop-2-ynyl-amino]pent-4-enoic acid ethyl ester

Chemical Property of (+)-(E,S_S,2S,3R)-5-[N-methyl-S-phenylsulfonimidoyl]-3-phenyl-2-[(2-methylprop-2-yl-sulfonyl)-prop-2-ynyl-amino]pent-4-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(E,S_S,2S,3R)-5-[N-methyl-S-phenylsulfonimidoyl]-3-phenyl-2-[(2-methylprop-2-yl-sulfonyl)-prop-2-ynyl-amino]pent-4-enoic acid ethyl ester

There total 3 articles about (+)-(E,S_S,2S,3R)-5-[N-methyl-S-phenylsulfonimidoyl]-3-phenyl-2-[(2-methylprop-2-yl-sulfonyl)-prop-2-ynyl-amino]pent-4-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

propargyl bromide (106-96-7) + C6H5C18H27O5N2S2 (445010-40-2) → (+)-(E,SS,2S,3R)-5-[N-methyl-S-phenylsulfonimidoyl]-3-phenyl-2-[(2-methylprop-2-yl-sulfonyl)-prop-2-ynyl-amino]pent-4-enoic acid ethyl ester (616234-13-0)

Guidance literature:

C₆H₅C₁₈H₂₇O₅N₂S₂; With CsCO₃; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

propargyl bromide; In N,N-dimethyl-formamide; toluene; at 0 - 20 ℃;

DOI:10.1021/jo030171x

Reference yield:

C6H5C10H12SON (159951-03-8) → (+)-(E,SS,2S,3R)-5-[N-methyl-S-phenylsulfonimidoyl]-3-phenyl-2-[(2-methylprop-2-yl-sulfonyl)-prop-2-ynyl-amino]pent-4-enoic acid ethyl ester (616234-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / -78 °C

1.2: ClTi(Oi-Pr)3 / tetrahydrofuran / -78 °C

1.3: 82 percent / tetrahydrofuran / -78 °C

2.1: CsCO₃ / dimethylformamide / 0.25 h / 20 °C

2.2: 96 percent / dimethylformamide; toluene / 0 - 20 °C

With n-butyllithium; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jo030171x

Reference yield:

(2-methyl-propane-2-sulfonylimino) acetic acid ethyl ester (445010-18-4) → (+)-(E,SS,2S,3R)-5-[N-methyl-S-phenylsulfonimidoyl]-3-phenyl-2-[(2-methylprop-2-yl-sulfonyl)-prop-2-ynyl-amino]pent-4-enoic acid ethyl ester (616234-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / -78 °C

1.2: ClTi(Oi-Pr)3 / tetrahydrofuran / -78 °C

1.3: 82 percent / tetrahydrofuran / -78 °C

2.1: CsCO₃ / dimethylformamide / 0.25 h / 20 °C

2.2: 96 percent / dimethylformamide; toluene / 0 - 20 °C

With n-butyllithium; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jo030171x

upstream raw materials:

propargyl bromide

C₆H₅C₁₈H₂₇O₅N₂S₂

C₆H₅C₁₀H₁₂SON

(2-methyl-propane-2-sulfonylimino) acetic acid ethyl ester

Downstream raw materials:

Benzenesulfinic acid (R)-methylamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 616234-13-0 (+)-(E,S_S,2S,3R)-5-[N-methyl-S-phenylsulfonimidoyl]-3-phenyl-2-[(2-methylprop-2-yl-sulfonyl)-prop-2-ynyl-amino]pent-4-enoic acid ethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send