(+)-(S)-N-methyl benzenesulfinamide

Base Information

• Chemical Name: (+)-(S)-N-methyl benzenesulfinamide
• CAS No.: 33957-73-2
• Molecular Formula: C₇H₉NOS
• Molecular Weight: 155.221
• Mol file: 33957-73-2.mol

Synonyms:(+)-(S)-N-methyl benzenesulfinamide

Chemical Property of (+)-(S)-N-methyl benzenesulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(S)-N-methyl benzenesulfinamide

There total 72 articles about (+)-(S)-N-methyl benzenesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C16H34CuO4(1-)*Li(1+) + [3'aR-(3'aα,5'(R*),6'aα)]-N-methyl-S-phenyl-S-{[3',3'a,4',6'a-tetrahydro-5,5-dimethylspiro(1,3-dioxan-2,2'(1'H)-pentalen)-5'-yl]methyl}sulfoximine (143962-63-4) → Benzenesulfinic acid (R)-methylamide (33957-73-2,69726-27-8,84413-63-8,33993-55-4) + (3'aR-(3'aα,6'aα))-3',3'a,4',6'a-tetrahydro-5'-[5-(1-ethoxyethoxy)pentyl]spiro[5,5-dimethyl-1,3-dioxan-2,2'-(1'H)-pentalen] (210296-01-8)

Guidance literature:

With dimethylsulfide; In diethyl ether; at -45 ℃; for 6h;

Reference yield: 85.0%

triethyl (-)-(E,2S,3R)-(3-isopropyl-5-[(S)-N-methyl-S-phenylsulfonimidoyl]pent-4-en-2-yloxy)silane (1058213-64-1) + phenyllithium (591-51-5) → biphenyl (92-52-4,1594-86-1) + triethyl (Z,2S,3R)-(3-isopropyl-5-phenylpent-4-en-2-yloxy)silane (1058213-80-1) + triethyl (E,2S,3R)-(3-isopropyl-5-phenylpent-4-en-2-yloxy)silane (1058213-78-7) + (7Z,9Z,5S,6R,12S)-3,3,14,14-tetraethyl-6,11-diisopropyl-5,12-dimethyl-8-phenyl-4,13-dioxa-3,14-disilahexadeca-7,9-diene + (+)-(S)-N-methyl benzenesulfinamide (33957-73-2)

Guidance literature:

triethyl (-)-(E,2S,3R)-(3-isopropyl-5-[(S)-N-methyl-S-phenylsulfonimidoyl]pent-4-en-2-yloxy)silane; phenyllithium; With copper(l) iodide; In diethyl ether; cyclohexane; at -15 - 0 ℃; for 3.5h; Inert atmosphere;

With ammonia; water; ammonium chloride; In diethyl ether; cyclohexane; at 0 ℃; Inert atmosphere;

DOI:10.1002/chem.200800455

Reference yield: 85.0%

C21H37NO2SSi (1058213-69-6) + phenyllithium (591-51-5) → triethyl (E,2S,3R)-(3-isopropyl-5-phenylpent-4-en-2-yloxy)silane (1058213-78-7) + (7E,9E,5S,6R,12S)-3,3,14,14-tetraethyl-6,11-diisopropyl-5,12-dimethyl-8-phenyl-4,13-dioxa-3,14-disilahexadeca-7,9-diene + (+)-(S)-N-methyl benzenesulfinamide (33957-73-2)

Guidance literature:

C₂₁H₃₇NO₂SSi; phenyllithium; With copper(l) iodide; In diethyl ether; cyclohexane; at -40 - 20 ℃; for 18h; Inert atmosphere;

With ammonia; water; ammonium chloride; In diethyl ether; cyclohexane; at 20 ℃; optical yield given as %de; Inert atmosphere;

DOI:10.1002/chem.200800455

upstream raw materials:

bis((trimethylsilyl)methyl)zinc

C₁₈H₂₇NOS

N¹,N¹,N²-Trimethyl-benzolsulfonamidin

N,S-dimethyl-S-phenylsulfoximine

Downstream raw materials:

(+)-(S)-Phenyl-N-methylbenzolsulfonimidat

N¹,N¹,N²-Trimethyl-benzolsulfonamidin

N,S-dimethyl-S-phenylsulfoximine

S-butyl-N-methyl-S-phenylsulfoximine