(1S,2S)-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol (2S,3S)-2,3-bis(4-methylbenzoyloxy)succinate

Base Information

Chemical Name:(1S,2S)-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol (2S,3S)-2,3-bis(4-methylbenzoyloxy)succinate
CAS No.:1373215-27-0
Molecular Formula:C₁₀H₁₂BrNO*C₂₀H₁₈O₈
Molecular Weight:628.474
Hs Code.:

Synonyms:(1S,2S)-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol (2S,3S)-2,3-bis(4-methylbenzoyloxy)succinate

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Chemical Property of (1S,2S)-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol (2S,3S)-2,3-bis(4-methylbenzoyloxy)succinate

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Technology Process of (1S,2S)-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol (2S,3S)-2,3-bis(4-methylbenzoyloxy)succinate

There total 5 articles about (1S,2S)-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol (2S,3S)-2,3-bis(4-methylbenzoyloxy)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: (+/-)-trans-1-amino-7-bromotetralin-2-ol

: 32634-68-7
(2S,3S)-di-4-toluoyltartaric acid

: 1373215-27-0
(1S,2S)-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol (2S,3S)-2,3-bis(4-methylbenzoyloxy)succinate

Guidance literature:: In water; acetonitrile; at 20 - 77 ℃; Reflux; Inert atmosphere; Industry scale;

Reference yield: 22.0%

: (+/-)-trans-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol

: 32634-68-7
(2S,3S)-di-4-toluoyltartaric acid

: 1373215-27-0
(1S,2S)-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol (2S,3S)-2,3-bis(4-methylbenzoyloxy)succinate

Guidance literature:: In water; acetonitrile; at 77 ℃; for 0.5h; Inert atmosphere; Resolution of racemate;
DOI:10.1021/ml500283g

Reference yield:

: 75693-17-3
bromo-7 dihydro-3,4 naphthalene

: 1373215-27-0
(1S,2S)-1-amino-7-bromo-1,2,3,4-tetrahydronaphthalen-2-ol (2S,3S)-2,3-bis(4-methylbenzoyloxy)succinate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane; water / 4 h / 0 - 20 °C / Industry scale

2: ammonia / tetrahydrofuran; methanol / 72 h / 70 °C / Sealed the reactor

3: acetonitrile; water / 20 - 77 °C / Reflux; Inert atmosphere; Industry scale

With ammonia; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;