5′-O-(4,4′-dimethoxytrityl)-2′-O,4′-C-methylenethymidine-3′-[O-(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Base Information

Chemical Name:5′-O-(4,4′-dimethoxytrityl)-2′-O,4′-C-methylenethymidine-3′-[O-(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
CAS No.:206055-76-7
Molecular Formula:C₄₀H₄₇N₄O₉P
Molecular Weight:758.808
Hs Code.:

Synonyms:5′-O-(4,4′-dimethoxytrityl)-2′-O,4′-C-methylenethymidine-3′-[O-(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Suppliers and Price of 5′-O-(4,4′-dimethoxytrityl)-2′-O,4′-C-methylenethymidine-3′-[O-(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of 5′-O-(4,4′-dimethoxytrityl)-2′-O,4′-C-methylenethymidine-3′-[O-(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 5′-O-(4,4′-dimethoxytrityl)-2′-O,4′-C-methylenethymidine-3′-[O-(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

There total 24 articles about 5′-O-(4,4′-dimethoxytrityl)-2′-O,4′-C-methylenethymidine-3′-[O-(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 195705-32-9
5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methyleneuridine

: 206055-76-7
5′-O-(4,4′-dimethoxytrityl)-2′-O,4′-C-methylenethymidine-3′-[O-(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/S0960-894X(00)00434-0

Reference yield: 81.0%

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 195705-32-9
5'-O-(4,4'-dimethoxytrityl)-2'-O,4'-C-methyleneuridine

: 206055-76-7
5′-O-(4,4′-dimethoxytrityl)-2′-O,4′-C-methylenethymidine-3′-[O-(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Guidance literature:: With N,N-diisopropylamine tetrazolide; In tetrahydrofuran; acetonitrile; for 1.5h; Ambient temperature;
DOI:10.1016/S0040-4039(98)01084-3

Reference yield:

: 350505-61-2
2',3'-O-benzylidene-4'-(p-toluenesulfonyloxymethyl)uridine

: 206055-76-7
5′-O-(4,4′-dimethoxytrityl)-2′-O,4′-C-methylenethymidine-3′-[O-(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / NaBH₃CN; TiCl₄ / acetonitrile / 15 h / 0 °C

2: 61 percent / NaN(SiMe₃)2 / tetrahydrofuran / 3 h / 20 °C

3: 100 percent / H₂ / Pd/C / methanol / 15 h / 20 °C

4: 94 percent / DMAP; pyridine / 5 h / 20 °C

5: 81 percent / diisopropylammonium tetrazolide / acetonitrile; tetrahydrofuran / 1.5 h / 20 °C

With pyridine; dmap; N,N-diisopropylamine tetrazolide; hydrogen; sodium hexamethyldisilazane; titanium tetrachloride; sodium cyanoborohydride; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/S0968-0896(00)00325-4