1-phenyl-4-[3,5-bis(hydroxymethyl)phenyl]-1H-1,2,3-triazole

Base Information

Chemical Name:1-phenyl-4-[3,5-bis(hydroxymethyl)phenyl]-1H-1,2,3-triazole
CAS No.:1279101-47-1
Molecular Formula:C₁₆H₁₅N₃O₂
Molecular Weight:281.314
Hs Code.:

Synonyms:1-phenyl-4-[3,5-bis(hydroxymethyl)phenyl]-1H-1,2,3-triazole

Suppliers and Price of 1-phenyl-4-[3,5-bis(hydroxymethyl)phenyl]-1H-1,2,3-triazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-phenyl-4-[3,5-bis(hydroxymethyl)phenyl]-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-phenyl-4-[3,5-bis(hydroxymethyl)phenyl]-1H-1,2,3-triazole

There total 4 articles about 1-phenyl-4-[3,5-bis(hydroxymethyl)phenyl]-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 622-37-7
Phenyl azide

: 3,5-bis(hydroxymethyl)ethynylbenzene

: 1279101-47-1
1-phenyl-4-[3,5-bis(hydroxymethyl)phenyl]-1H-1,2,3-triazole

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In ethanol; for 8h; Inert atmosphere;
DOI:10.1039/c0cc04979d

Reference yield:

: 99-27-4
dimethyl 5-aminoisophthalate

: 1279101-47-1
1-phenyl-4-[3,5-bis(hydroxymethyl)phenyl]-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / water / 2 h / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 20 °C / Inert atmosphere

2.1: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / 12 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

3.2: Cooling with ice; Inert atmosphere

4.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / ethanol / 8 h / Inert atmosphere

With piperidine; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium aluminium tetrahydride; copper(ll) sulfate pentahydrate; sodium L-ascorbate; triphenylphosphine; sodium nitrite; In tetrahydrofuran; ethanol; water; 2.1: Sonogashira coupling;
DOI:10.1039/c0cc04979d

Reference yield:

: 51839-15-7
5-iodo-isophthalic acid dimethyl ester

: 1279101-47-1
1-phenyl-4-[3,5-bis(hydroxymethyl)phenyl]-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: piperidine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / 12 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere

2.2: Cooling with ice; Inert atmosphere

3.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / ethanol / 8 h / Inert atmosphere

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; lithium aluminium tetrahydride; copper(ll) sulfate pentahydrate; sodium L-ascorbate; triphenylphosphine; In tetrahydrofuran; ethanol; 1.1: Sonogashira coupling;
DOI:10.1039/c0cc04979d