Technology Process of N-[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(5-bromo-2-fluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide
There total 8 articles about N-[(4aR,6R,8aS)-6-[(benzyloxy)methyl]-8a-(5-bromo-2-fluorophenyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine; trifluoromethylsulfonic anhydride;
In
dichloromethane;
at -55 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: formic acid; water / 2.5 h / 20 °C
1.2: 18 h / 20 °C
2.1: sodium hypochlorite / water; dichloromethane / 1.5 h / 0 - 15 °C
3.1: boron trifluoride diethyl etherate / toluene / 0.5 h / -78 °C
3.2: 1.5 h / -78 °C
4.1: molybdenum hexacarbonyl; water / acetonitrile / 0.5 h / Reflux
4.2: 3 h / Reflux
5.1: dichloromethane / 48 h / 20 °C
6.1: pyridine; trifluoromethylsulfonic anhydride / dichloromethane / 2 h / -50 - 0 °C
With
pyridine; sodium hypochlorite; formic acid; trifluoromethylsulfonic anhydride; boron trifluoride diethyl etherate; water; molybdenum hexacarbonyl;
In
dichloromethane; water; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 30 °C
1.2: 19 h / 20 - 70 °C
2.1: formic acid; water / 2.5 h / 20 °C
2.2: 18 h / 20 °C
3.1: sodium hypochlorite / water; dichloromethane / 1.5 h / 0 - 15 °C
4.1: boron trifluoride diethyl etherate / toluene / 0.5 h / -78 °C
4.2: 1.5 h / -78 °C
5.1: molybdenum hexacarbonyl; water / acetonitrile / 0.5 h / Reflux
5.2: 3 h / Reflux
6.1: dichloromethane / 48 h / 20 °C
7.1: pyridine; trifluoromethylsulfonic anhydride / dichloromethane / 2 h / -50 - 0 °C
With
pyridine; sodium hypochlorite; formic acid; trifluoromethylsulfonic anhydride; boron trifluoride diethyl etherate; water; sodium hydride; molybdenum hexacarbonyl;
In
tetrahydrofuran; dichloromethane; water; toluene; acetonitrile; mineral oil;
![N-{[(3S,4R,6R)-6-[(benzyloxy)methyl]-3-(5-bromo-2-fluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide](/Databaselist/images/loading.webp)
