1-[1,3,5-trimethyl-1-pyrazol-4-yl]-2-[2-methyl-5-phenyl-1-thien-3-yl]perfluorocyclopentene

Base Information

Chemical Name:1-[1,3,5-trimethyl-1-pyrazol-4-yl]-2-[2-methyl-5-phenyl-1-thien-3-yl]perfluorocyclopentene
CAS No.:933995-28-9
Molecular Formula:C₂₂H₁₈F₆N₂S
Molecular Weight:456.455
Hs Code.:

Synonyms:1-[1,3,5-trimethyl-1-pyrazol-4-yl]-2-[2-methyl-5-phenyl-1-thien-3-yl]perfluorocyclopentene

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Chemical Property of 1-[1,3,5-trimethyl-1-pyrazol-4-yl]-2-[2-methyl-5-phenyl-1-thien-3-yl]perfluorocyclopentene

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Technology Process of 1-[1,3,5-trimethyl-1-pyrazol-4-yl]-2-[2-methyl-5-phenyl-1-thien-3-yl]perfluorocyclopentene

There total 5 articles about 1-[1,3,5-trimethyl-1-pyrazol-4-yl]-2-[2-methyl-5-phenyl-1-thien-3-yl]perfluorocyclopentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.1%

: 911689-65-1
1-(1,3,5-trimethyl-1-pyrazol-4-yl)perfluorocyclopentene

: 61285-25-4
3-bromo-2-methyl-5-phenylthiophene

: 933995-28-9
1-[1,3,5-trimethyl-1-pyrazol-4-yl]-2-[2-methyl-5-phenyl-1-thien-3-yl]perfluorocyclopentene

Guidance literature:: 3-bromo-2-methyl-5-phenylthiophene; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

1-(1,3,5-trimethyl-1-pyrazol-4-yl)perfluorocyclopentene; In tetrahydrofuran; at -78 ℃; Further stages.;
DOI:10.1139/V06-182

Reference yield:

: 554-14-3
2-Methylthiophene

: 933995-28-9
1-[1,3,5-trimethyl-1-pyrazol-4-yl]-2-[2-methyl-5-phenyl-1-thien-3-yl]perfluorocyclopentene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 81.2 percent / Br₂ / acetic acid / 0 °C

2.1: n-BuLi / diethyl ether; hexane / 0.5 h / -78 °C

2.2: 85.5 percent / boric acid tributyl ester / diethyl ether; hexane / -78 - 20 °C

3.1: 70 percent / Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 70 °C

4.1: n-BuLi / tetrahydrofuran / -78 °C

4.2: 44.1 percent / tetrahydrofuran / -78 °C

With n-butyllithium; bromine; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; hexane; acetic acid;
DOI:10.1139/V06-182

Reference yield:

: 154566-69-5
3-bromo-2-methylthiophene-5-boronic acid

: 933995-28-9
1-[1,3,5-trimethyl-1-pyrazol-4-yl]-2-[2-methyl-5-phenyl-1-thien-3-yl]perfluorocyclopentene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 70 percent / Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 70 °C

2.1: n-BuLi / tetrahydrofuran / -78 °C

2.2: 44.1 percent / tetrahydrofuran / -78 °C

With n-butyllithium; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;
DOI:10.1139/V06-182