ethyl (2E,4Z)-5-(4-cyclobutoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoate

Base Information

Chemical Name:ethyl (2E,4Z)-5-(4-cyclobutoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoate
CAS No.:1002128-17-7
Molecular Formula:C₂₄H₂₃F₃O₃
Molecular Weight:416.44
Hs Code.:

Synonyms:ethyl (2E,4Z)-5-(4-cyclobutoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoate

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Chemical Property of ethyl (2E,4Z)-5-(4-cyclobutoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoate

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Technology Process of ethyl (2E,4Z)-5-(4-cyclobutoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoate

There total 4 articles about ethyl (2E,4Z)-5-(4-cyclobutoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1002128-15-5
ethyl (2E,4Z)-5-(4-hydroxyphenyl)-5-(4-trifluoromethylphenyl)-2,4-pentadienoate

: 2919-23-5
cyclobutanol

: 1002128-17-7
ethyl (2E,4Z)-5-(4-cyclobutoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; at 20 ℃; for 48h;

Reference yield:

: 1002127-15-2
ethyl (E)-5,5-dibromo-2,4-pentadienoate

: 1002128-17-7
ethyl (2E,4Z)-5-(4-cyclobutoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 6 h / 70 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; sodium carbonate / 1,4-dioxane; water / 4.5 h / 70 °C / Inert atmosphere

3: triphenylphosphine; diethylazodicarboxylate / toluene / 13 h / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifuran-2-yl-phosphane; sodium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; water; toluene; 1: Suzuki coupling / 2: Suzuki coupling / 3: Mitsunobu reaction;
DOI:10.1021/jm300101n

Reference yield:

: 1002127-25-4
ethyl (2E,4Z)-5-bromo-5-(4-trifluoromethylphenyl)-2,4-pentadienoate

: 1002128-17-7
ethyl (2E,4Z)-5-(4-cyclobutoxyphenyl)-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienoate

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; sodium carbonate / 1,4-dioxane; water / 4.5 h / 70 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / toluene / 13 h / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; sodium carbonate; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; water; toluene; 1: Suzuki coupling / 2: Mitsunobu reaction;
DOI:10.1021/jm300101n