1-(4-methoxy-benzyl)-2,2-dimethyl-4-(5-nitro-pyridin-2-ylmethyl)-piperazine

Base Information

Chemical Name:1-(4-methoxy-benzyl)-2,2-dimethyl-4-(5-nitro-pyridin-2-ylmethyl)-piperazine
CAS No.:1197332-88-9
Molecular Formula:C₂₀H₂₆N₄O₃
Molecular Weight:370.451
Hs Code.:

Synonyms:1-(4-methoxy-benzyl)-2,2-dimethyl-4-(5-nitro-pyridin-2-ylmethyl)-piperazine

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Chemical Property of 1-(4-methoxy-benzyl)-2,2-dimethyl-4-(5-nitro-pyridin-2-ylmethyl)-piperazine

Chemical Property:

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Technology Process of 1-(4-methoxy-benzyl)-2,2-dimethyl-4-(5-nitro-pyridin-2-ylmethyl)-piperazine

There total 7 articles about 1-(4-methoxy-benzyl)-2,2-dimethyl-4-(5-nitro-pyridin-2-ylmethyl)-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197332-89-0
methanesulfonic acid 5-nitro-pyridin-2-ylmethyl ester

: 1197332-72-1
1-(4-methoxy-benzyl)-2,2-dimethyl-piperazine

: 1197332-88-9
1-(4-methoxy-benzyl)-2,2-dimethyl-4-(5-nitro-pyridin-2-ylmethyl)-piperazine

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

Reference yield:

: 4487-59-6
2-bromo-5-nitropyridine

: 1197332-88-9
1-(4-methoxy-benzyl)-2,2-dimethyl-4-(5-nitro-pyridin-2-ylmethyl)-piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) cyanide / N,N-dimethyl-formamide / 0.25 h / Reflux; Inert atmosphere

2: sulfuric acid / 1.5 h / Reflux

3: diisobutylaluminium hydride / dichloromethane / -78 - 20 °C

4: triethylamine / dichloromethane / 0.5 h / 5 °C / Inert atmosphere

5: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

With sulfuric acid; copper(l) cyanide; diisobutylaluminium hydride; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 30651-24-2
5-nitropicolinic acid

: 1197332-88-9
1-(4-methoxy-benzyl)-2,2-dimethyl-4-(5-nitro-pyridin-2-ylmethyl)-piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 1.5 h / Reflux

2: diisobutylaluminium hydride / dichloromethane / -78 - 20 °C

3: triethylamine / dichloromethane / 0.5 h / 5 °C / Inert atmosphere

4: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

With sulfuric acid; diisobutylaluminium hydride; caesium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;