6-[4-(4-methoxy-benzyl)-3,3-dimethyl-piperazin-1-ylmethyl]-pyridin-3-ylamine

Base Information

Chemical Name:6-[4-(4-methoxy-benzyl)-3,3-dimethyl-piperazin-1-ylmethyl]-pyridin-3-ylamine
CAS No.:1197332-86-7
Molecular Formula:C₂₀H₂₈N₄O
Molecular Weight:340.469
Hs Code.:

Synonyms:6-[4-(4-methoxy-benzyl)-3,3-dimethyl-piperazin-1-ylmethyl]-pyridin-3-ylamine

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Chemical Property of 6-[4-(4-methoxy-benzyl)-3,3-dimethyl-piperazin-1-ylmethyl]-pyridin-3-ylamine

Chemical Property:

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Technology Process of 6-[4-(4-methoxy-benzyl)-3,3-dimethyl-piperazin-1-ylmethyl]-pyridin-3-ylamine

There total 8 articles about 6-[4-(4-methoxy-benzyl)-3,3-dimethyl-piperazin-1-ylmethyl]-pyridin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1197332-88-9
1-(4-methoxy-benzyl)-2,2-dimethyl-4-(5-nitro-pyridin-2-ylmethyl)-piperazine

: 1197332-86-7
6-[4-(4-methoxy-benzyl)-3,3-dimethyl-piperazin-1-ylmethyl]-pyridin-3-ylamine

Guidance literature:: With hydrogen; nickel; In tetrahydrofuran; methanol; at 20 ℃; for 20h;

Reference yield:

: 22476-74-0
3,3-dimethyl-piperazin-2-one

: 1197332-86-7
6-[4-(4-methoxy-benzyl)-3,3-dimethyl-piperazin-1-ylmethyl]-pyridin-3-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 120 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

3: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

4: hydrogen / nickel / tetrahydrofuran; methanol / 20 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; caesium carbonate; triethylamine; nickel; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 36625-57-7
(5-nitropyridin-2-yl)methanol

: 1197332-86-7
6-[4-(4-methoxy-benzyl)-3,3-dimethyl-piperazin-1-ylmethyl]-pyridin-3-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.5 h / 5 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 5 h / 20 °C

3: hydrogen / nickel / tetrahydrofuran; methanol / 20 h / 20 °C

With hydrogen; caesium carbonate; triethylamine; nickel; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;