1-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-3-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-urea

Base Information

• Chemical Name: 1-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-3-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-urea
• CAS No.: 405551-87-3
• Molecular Formula: C₄₁H₄₀ClN₅O
• Molecular Weight: 654.255
• Mol file: 405551-87-3.mol

Synonyms:1-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-3-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-urea

Chemical Property of 1-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-3-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-3-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-urea

There total 5 articles about 1-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-3-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4-(1-trityl-1H-imidazol-4-yl)butan-1-amine (195053-83-9) + 2-[1-(4-chloro-phenyl)-3-isocyanato-propyl]-pyridine (405551-74-8) → 1-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-3-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-urea (405551-87-3)

Guidance literature:

With pyridine;

DOI:10.1016/S0960-894X(03)00357-3

Reference yield:

2-(4-chlorobenzoyl)pyridine (6318-51-0) → 1-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-3-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-urea (405551-87-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / NaH / tetrahydrofuran

2: 78 percent / NaBH₄ / propan-2-ol / Heating

3: 36 percent / LiAlH₄ / diethyl ether / Heating

4: 100 percent / pyridine

5: 50 percent / pyridine

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; diethyl ether; isopropyl alcohol; 1: Horner-Wadsworth-Emmons olefination;

DOI:10.1016/S0960-894X(03)00357-3

Reference yield:

3-(4-chlorophenyl)-3-(pyridin-2-yl)propanenitrile (405551-70-4) → 1-[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-3-[4-(1-trityl-1H-imidazol-4-yl)-butyl]-urea (405551-87-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 36 percent / LiAlH₄ / diethyl ether / Heating

2: 100 percent / pyridine

3: 50 percent / pyridine

With pyridine; lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1016/S0960-894X(03)00357-3

upstream raw materials:

4-(1-trityl-1H-imidazol-4-yl)butan-1-amine

2-[1-(4-chloro-phenyl)-3-isocyanato-propyl]-pyridine

2-(4-chlorobenzoyl)pyridine

Didesmethylchlorpheniramine