methyl 3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-(3,4-methylenedioxyphenyl)methylpropanoate

Base Information

Chemical Name:methyl 3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-(3,4-methylenedioxyphenyl)methylpropanoate
CAS No.:134405-98-4
Molecular Formula:C₂₈H₃₁ClN₂O₆
Molecular Weight:527.017
Hs Code.:

Synonyms:methyl 3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-(3,4-methylenedioxyphenyl)methylpropanoate

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Chemical Property of methyl 3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-(3,4-methylenedioxyphenyl)methylpropanoate

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Technology Process of methyl 3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-(3,4-methylenedioxyphenyl)methylpropanoate

There total 9 articles about methyl 3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-(3,4-methylenedioxyphenyl)methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17849-38-6
2-Chlorobenzyl alcohol

: 134405-98-4
methyl 3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-(3,4-methylenedioxyphenyl)methylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: diisopropylethylamine / CH₂Cl₂ / 0.33 h / -78 °C

2: CH₂Cl₂ / 18 h / Ambient temperature

3: 10percent aq. NaOH / methanol / 4 h / Heating

4: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

6: (dimethylamino)pyridine / CH₂Cl₂ / 16 h

With dmap; manganese(IV) oxide; sodium hydroxide; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In methanol; dichloromethane;
DOI:10.1021/jm00099a013

Reference yield:

: 68283-19-2
2-n-butyl-4-(hydroxymethyl)imidazole

: 134405-98-4
methyl 3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-(3,4-methylenedioxyphenyl)methylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / 19 h / Ambient temperature

2: CH₂Cl₂ / 18 h / Ambient temperature

3: 10percent aq. NaOH / methanol / 4 h / Heating

4: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

5: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

6: (dimethylamino)pyridine / CH₂Cl₂ / 16 h

With dmap; manganese(IV) oxide; sodium hydroxide; lithium diisopropyl amide; In methanol; dichloromethane;
DOI:10.1021/jm00099a013

Reference yield:

: 133486-41-6
1-acetyl-4-acetoxymethyl-2-n-butylimidazole

: 134405-98-4
methyl 3-acetoxy-3-[2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-yl]-2-(3,4-methylenedioxyphenyl)methylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: CH₂Cl₂ / 18 h / Ambient temperature

2: 10percent aq. NaOH / methanol / 4 h / Heating

3: 93 percent / MnO₂ / CH₂Cl₂ / 19 h / Ambient temperature

4: 1.) LDA / 1.) THF, hexane, -78 deg C, 60 min, 2.) THF, hexane, -78 deg C, 10 min

5: (dimethylamino)pyridine / CH₂Cl₂ / 16 h

With dmap; manganese(IV) oxide; sodium hydroxide; lithium diisopropyl amide; In methanol; dichloromethane;
DOI:10.1021/jm00099a013