(R)-ethyl 2-(4-(aminomethyl)phenylamino)-3-methylbutanoate hydrochloride

Base Information

• Chemical Name: (R)-ethyl 2-(4-(aminomethyl)phenylamino)-3-methylbutanoate hydrochloride
• CAS No.: 1041612-30-9
• Molecular Formula: C₁₄H₂₂N₂O₂*ClH
• Molecular Weight: 286.802

Synonyms:(R)-ethyl 2-(4-(aminomethyl)phenylamino)-3-methylbutanoate hydrochloride

Chemical Property of (R)-ethyl 2-(4-(aminomethyl)phenylamino)-3-methylbutanoate hydrochloride

Chemical Property:

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Technology Process of (R)-ethyl 2-(4-(aminomethyl)phenylamino)-3-methylbutanoate hydrochloride

There total 7 articles about (R)-ethyl 2-(4-(aminomethyl)phenylamino)-3-methylbutanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-ethyl 2-(4-((tert-butoxycarbonylamino)methyl)phenylamino)-3-methylbutanoate (1283679-35-5) → (R)-ethyl 2-(4-(aminomethyl)phenylamino)-3-methylbutanoate hydrochloride (1041612-30-9)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 12h;

DOI:10.1016/j.bmcl.2011.01.041

Reference yield:

C12H14N2O2 → (R)-ethyl 2-(4-(aminomethyl)phenylamino)-3-methylbutanoate hydrochloride (1041612-30-9)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 2 h

2: sodium tetrahydroborate; nickel dichloride / ethanol / 0.33 h / 20 °C

3: sodium hydrogencarbonate / 3 h / 20 °C

4: hydrogenchloride; water / 1,4-dioxane / 12 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; water; sodium hydrogencarbonate; potassium carbonate; nickel dichloride; In 1,4-dioxane; ethanol; acetone;

DOI:10.1016/j.bmcl.2011.01.041

Reference yield:

C14H22N2O2 (1041629-69-9) → (R)-ethyl 2-(4-(aminomethyl)phenylamino)-3-methylbutanoate hydrochloride (1041612-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / 3 h / 20 °C

2: hydrogenchloride; water / 1,4-dioxane / 12 h / 20 °C

With hydrogenchloride; water; sodium hydrogencarbonate; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2011.01.041

upstream raw materials:

C₁₄H₂₂N₂O₂

(R)-ethyl 2-(4-((tert-butoxycarbonylamino)methyl)phenylamino)-3-methylbutanoate

(R)-ethyl 2-(4-cyanophenylamino)-3-methylbutanoate

D-Val-OH

Downstream raw materials:

(R)-ethyl 2-(4-(((S)-3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)-butanoyl)thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoate

(R)-2-(4-(((S)-3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoic acid

(R)-2-(4-(((S)-3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)-thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoic acid

(R)-ethyl 2-(4-(((S)-3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoate hydrochloride

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