tert-butyl ((4aS,5S,7aS)-3-ethyl-7a-(2-fluorophenyl)-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

Base Information

Chemical Name:tert-butyl ((4aS,5S,7aS)-3-ethyl-7a-(2-fluorophenyl)-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate
CAS No.:1262799-46-1
Molecular Formula:C₂₀H₂₃F₄N₃O₄
Molecular Weight:445.414
Hs Code.:

Synonyms:tert-butyl ((4aS,5S,7aS)-3-ethyl-7a-(2-fluorophenyl)-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

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Chemical Property of tert-butyl ((4aS,5S,7aS)-3-ethyl-7a-(2-fluorophenyl)-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

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Technology Process of tert-butyl ((4aS,5S,7aS)-3-ethyl-7a-(2-fluorophenyl)-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

There total 10 articles about tert-butyl ((4aS,5S,7aS)-3-ethyl-7a-(2-fluorophenyl)-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 180150-75-8
tert-butyl N-(ethylcarbamothioyl)carbamate

: (2S,3S,4S)-methyl 4-amino-4-(2-fluorophenyl)-2-(trifluoromethyl)tetrahydrofuran-3-carboxylate

: 1262799-46-1
tert-butyl ((4aS,5S,7aS)-3-ethyl-7a-(2-fluorophenyl)-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 - 50 ℃; Inert atmosphere;

Reference yield:

: 4248-19-5
tert-butyl carbazate

: 1262799-46-1
tert-butyl ((4aS,5S,7aS)-3-ethyl-7a-(2-fluorophenyl)-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 5 - 20 °C / Inert atmosphere; Ice bath

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

With sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

Reference yield:

: C₆H₇F₃O₃

: 1262799-46-1
tert-butyl ((4aS,5S,7aS)-3-ethyl-7a-(2-fluorophenyl)-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 1.08 h / Ice-cooling

1.2: 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1.42 h / -78 - -60 °C / Inert atmosphere

2.2: 2 h / -60 °C

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.33 h / 50 °C

4.1: hydroquinone / xylenes / 22 h / 140 °C

5.1: zinc; acetic acid / 0 - 20 °C

6.1: chromium(VI) oxide; sulfuric acid / water; acetone / 72 h / 20 °C

7.1: sulfuric acid / 20 °C / Inert atmosphere; Reflux

8.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

With chromium(VI) oxide; n-butyllithium; sulfuric acid; hydroxylamine hydrochloride; sodium acetate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; hydroquinone; 1,1'-carbonyldiimidazole; zinc; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; xylenes;