(4aS,5S,7aS)-2-amino-3-ethyl-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydrofuro[3,4-d]pyrimidin-4(3H)-one

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Chemical Name:(4aS,5S,7aS)-2-amino-3-ethyl-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydrofuro[3,4-d]pyrimidin-4(3H)-one
CAS No.:1262799-47-2
Molecular Formula:C₁₅H₁₄F₄N₄O₄
Molecular Weight:390.294
Hs Code.:

Synonyms:(4aS,5S,7aS)-2-amino-3-ethyl-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydrofuro[3,4-d]pyrimidin-4(3H)-one

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Chemical Property of (4aS,5S,7aS)-2-amino-3-ethyl-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydrofuro[3,4-d]pyrimidin-4(3H)-one

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Technology Process of (4aS,5S,7aS)-2-amino-3-ethyl-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydrofuro[3,4-d]pyrimidin-4(3H)-one

There total 10 articles about (4aS,5S,7aS)-2-amino-3-ethyl-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydrofuro[3,4-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262799-46-1
tert-butyl ((4aS,5S,7aS)-3-ethyl-7a-(2-fluorophenyl)-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate

: 1262799-47-2
(4aS,5S,7aS)-2-amino-3-ethyl-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydrofuro[3,4-d]pyrimidin-4(3H)-one

Guidance literature:: tert-butyl ((4aS,5S,7aS)-3-ethyl-7a-(2-fluorophenyl)-4-oxo-5-(trifluoromethyl)-3,4,4a,5,7,7a-hexahydrofuro[3,4-d]pyrimidin-2-yl)carbamate; With nitric acid; at 20 ℃; for 24h;

With sodium hydroxide; In water;

Reference yield:

: C₆H₇F₃O₃

: 1262799-47-2
(4aS,5S,7aS)-2-amino-3-ethyl-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydrofuro[3,4-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 1.08 h / Ice-cooling

1.2: 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 1.42 h / -78 - -60 °C / Inert atmosphere

2.2: 2 h / -60 °C

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.33 h / 50 °C

4.1: hydroquinone / xylenes / 22 h / 140 °C

5.1: zinc; acetic acid / 0 - 20 °C

6.1: chromium(VI) oxide; sulfuric acid / water; acetone / 72 h / 20 °C

7.1: sulfuric acid / 20 °C / Inert atmosphere; Reflux

8.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

9.1: nitric acid / 24 h / 20 °C

With chromium(VI) oxide; n-butyllithium; sulfuric acid; hydroxylamine hydrochloride; nitric acid; sodium acetate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; hydroquinone; 1,1'-carbonyldiimidazole; zinc; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; xylenes;

Reference yield:

: 1262799-37-0
tert-butyl {[(2S)-1,1,1-trifluorobut-3-en-2-yl]oxy}acetate

: 1262799-47-2
(4aS,5S,7aS)-2-amino-3-ethyl-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydrofuro[3,4-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: formic acid / 20 °C / Ice-cooling

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 1.08 h / Ice-cooling

2.2: 20 °C

3.1: n-butyllithium / hexane; tetrahydrofuran / 1.42 h / -78 - -60 °C / Inert atmosphere

3.2: 2 h / -60 °C

4.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.33 h / 50 °C

5.1: hydroquinone / xylenes / 22 h / 140 °C

6.1: zinc; acetic acid / 0 - 20 °C

7.1: chromium(VI) oxide; sulfuric acid / water; acetone / 72 h / 20 °C

8.1: sulfuric acid / 20 °C / Inert atmosphere; Reflux

9.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

10.1: nitric acid / 24 h / 20 °C

With chromium(VI) oxide; n-butyllithium; formic acid; sulfuric acid; hydroxylamine hydrochloride; nitric acid; sodium acetate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; hydroquinone; 1,1'-carbonyldiimidazole; zinc; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; xylenes;