C₃₆H₂₈ClF₃N₈

Base Information

• Chemical Name: C₃₆H₂₈ClF₃N₈
• CAS No.: 1337567-06-2
• Molecular Formula: C₃₆H₂₈ClF₃N₈
• Molecular Weight: 665.12
• Mol file: 1337567-06-2.mol

Synonyms:C₃₆H₂₈ClF₃N₈

Chemical Property of C₃₆H₂₈ClF₃N₈

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₂₈ClF₃N₈

There total 11 articles about C₃₆H₂₈ClF₃N₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C32H23BrClF3N6 (1337567-05-1) + 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (761446-44-0) → C36H28ClF3N8 (1337567-06-2)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 0.0833333h; microwave irradiation;

Reference yield:

benzylamine (100-46-9) → C36H28ClF3N8 (1337567-06-2)

Guidance literature:

Multi-step reaction with 8 steps

1: 0.33 h / Cooling with ice

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.67 h / -78 - 20 °C

3: hydrazine / 1,4-dioxane / 1 h / 20 °C

4: boron trifluoride diethyl etherate / methanol / 1.5 h / 100 °C / sealed tube

5: ethylenediamine; copper(l) iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C

6: 0.75 h / 140 °C

7: bromine; acetic acid / 20 °C

8: potassium carbonate / 1,4-dioxane; water / 0.08 h / 90 °C / microwave irradiation

With copper(l) iodide; boron trifluoride diethyl etherate; bromine; potassium carbonate; acetic acid; ethylenediamine; 3-chloro-benzenecarboperoxoic acid; hydrazine; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

methyl-2-bromo-5-chlorobenzoate (27007-53-0) → C36H28ClF3N8 (1337567-06-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - 0 °C

1.2: 1 h / 20 °C

2.1: boron trifluoride diethyl etherate / methanol / 1.5 h / 100 °C / sealed tube

3.1: ethylenediamine; copper(l) iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.1: 0.75 h / 140 °C

5.1: bromine; acetic acid / 20 °C

6.1: potassium carbonate / 1,4-dioxane; water / 0.08 h / 90 °C / microwave irradiation

With copper(l) iodide; boron trifluoride diethyl etherate; bromine; sodium hexamethyldisilazane; potassium carbonate; acetic acid; ethylenediamine; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

benzylamine

2-(2,3,6-trifluorophenyl)acetic acid

methyl-2-bromo-5-chlorobenzoate

C₃₂H₂₃BrClF₃N₆

Downstream raw materials:

2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]-5-(1-methyl-1H-pyrazol-4-yl)pyrimidine-4,6-diamine