(R)-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Base Information

Chemical Name:(R)-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine
CAS No.:1352415-47-4
Molecular Formula:C₁₇H₁₉N₃O₂
Molecular Weight:297.357
Hs Code.:

Synonyms:(R)-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

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Chemical Property of (R)-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

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Technology Process of (R)-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

There total 9 articles about (R)-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352415-46-3
rac-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

: 1352415-47-4
(R)-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

: (S)-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: With Chiralpak Daicel; In methanol; carbon dioxide; isopropylamine; Resolution of racemate;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1352415-47-4
(R)-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

: (S)-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium chloride / ammonia; methanol / 96 h / 20 °C

2.1: hydrogenchloride / 96 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

4.2: 1.5 h / -15 - 0 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

6.1: tetraphosphorus decasulfide / tetrahydrofuran / 1 h / 20 - 50 °C

6.2: 5 h / 80 °C

7.1: ammonia / water; methanol / 6 h / 60 °C

8.1: Chiralpak_.(R). Daicel / carbon dioxide; isopropylamine; methanol / Resolution of racemate

With hydrogenchloride; lithium aluminium tetrahydride; tetraphosphorus decasulfide; ammonia; ammonium chloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; carbon dioxide; ammonia; water; isopropylamine;

Reference yield:

: 1183013-69-5
(RS)-2-amino-2-(3-bromo-phenyl)-propan-1-ol

: 1352415-47-4
(R)-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

: (S)-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

1.2: 1.5 h / -15 - 0 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

3.1: tetraphosphorus decasulfide / tetrahydrofuran / 1 h / 20 - 50 °C

3.2: 5 h / 80 °C

4.1: ammonia / water; methanol / 6 h / 60 °C

5.1: Chiralpak_.(R). Daicel / carbon dioxide; isopropylamine; methanol / Resolution of racemate

With tetraphosphorus decasulfide; ammonia; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; carbon dioxide; water; isopropylamine;