N-methoxy-N-methyl-2-(4-(prop-2-ynyloxy)phenyl)-1H-benzo-[d]imidazole-6-carboxamide

Base Information

• Chemical Name: N-methoxy-N-methyl-2-(4-(prop-2-ynyloxy)phenyl)-1H-benzo-[d]imidazole-6-carboxamide
• CAS No.: 1268487-52-0
• Molecular Formula: C₁₉H₁₇N₃O₃
• Molecular Weight: 335.362

Synonyms:N-methoxy-N-methyl-2-(4-(prop-2-ynyloxy)phenyl)-1H-benzo-[d]imidazole-6-carboxamide

Chemical Property of N-methoxy-N-methyl-2-(4-(prop-2-ynyloxy)phenyl)-1H-benzo-[d]imidazole-6-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methoxy-N-methyl-2-(4-(prop-2-ynyloxy)phenyl)-1H-benzo-[d]imidazole-6-carboxamide

There total 5 articles about N-methoxy-N-methyl-2-(4-(prop-2-ynyloxy)phenyl)-1H-benzo-[d]imidazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-(prop-2-ynyloxy)benzaldehyde (5651-86-5) + N-methoxy N-methyl 3,4-dinitrobenzoic acid amide (391903-19-8) → N-methoxy-N-methyl-2-(4-(prop-2-ynyloxy)phenyl)-1H-benzo-[d]imidazole-6-carboxamide (1268487-52-0)

Guidance literature:

N-methoxy N-methyl 3,4-dinitrobenzoic acid amide; With palladium 10% on activated carbon; hydrogen; In ethanol; for 5h; under 760.051 Torr;

4-(prop-2-ynyloxy)benzaldehyde; With sodium metabisulfite; In ethanol; water; for 12h; Reflux;

Reference yield:

4-(prop-2-ynyloxy)benzaldehyde (5651-86-5) + N-methoxy N-methyl 3,4-diaminobenzoic acid amide (660432-02-0) → N-methoxy-N-methyl-2-(4-(prop-2-ynyloxy)phenyl)-1H-benzo-[d]imidazole-6-carboxamide (1268487-52-0)

Guidance literature:

With sodium metabisulfite; In water; for 12h; Reflux;

DOI:10.1039/c4md00140k

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → N-methoxy-N-methyl-2-(4-(prop-2-ynyloxy)phenyl)-1H-benzo-[d]imidazole-6-carboxamide (1268487-52-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane; 1,4-dioxane / 0 - 20 °C / Inert atmosphere; Cooling with ice

2: sodium metabisulfite / water / 12 h / Reflux

With sodium metabisulfite; di-isopropyl azodicarboxylate; triphenylphosphine; In 1,4-dioxane; dichloromethane; water; 1: |Mitsunobu Displacement;

DOI:10.1039/c4md00140k

upstream raw materials:

4-hydroxy-benzaldehyde

4-(prop-2-ynyloxy)benzaldehyde

N-methoxy N-methyl 3,4-diaminobenzoic acid amide

N-methoxy N-methyl 3,4-dinitrobenzoic acid amide

Downstream raw materials:

2-(4-(prop-2-ynyloxy)phenyl)-1H-benzo[d]imidazole-6-carbaldehyde

6-(4-methylpiperazin-1-yl)-2'-(4-(prop-2-ynyloxy)phenyl)-1H,3'H-2,5'-bibenzo[d]imidazole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1268487-52-0 N-methoxy-N-methyl-2-(4-(prop-2-ynyloxy)phenyl)-1H-benzo-[d]imidazole-6-carboxamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send