6-(4-methylpiperazin-1-yl)-2'-(4-(prop-2-ynyloxy)phenyl)-1H,3'H-2,5'-bibenzo[d]imidazole

Base Information

Chemical Name:6-(4-methylpiperazin-1-yl)-2'-(4-(prop-2-ynyloxy)phenyl)-1H,3'H-2,5'-bibenzo[d]imidazole
CAS No.:1268487-56-4
Molecular Formula:C₂₈H₂₆N₆O
Molecular Weight:462.554
Hs Code.:

Synonyms:6-(4-methylpiperazin-1-yl)-2'-(4-(prop-2-ynyloxy)phenyl)-1H,3'H-2,5'-bibenzo[d]imidazole

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Chemical Property of 6-(4-methylpiperazin-1-yl)-2'-(4-(prop-2-ynyloxy)phenyl)-1H,3'H-2,5'-bibenzo[d]imidazole

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Technology Process of 6-(4-methylpiperazin-1-yl)-2'-(4-(prop-2-ynyloxy)phenyl)-1H,3'H-2,5'-bibenzo[d]imidazole

There total 10 articles about 6-(4-methylpiperazin-1-yl)-2'-(4-(prop-2-ynyloxy)phenyl)-1H,3'H-2,5'-bibenzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1268487-54-2
2-(4-(prop-2-ynyloxy)phenyl)-1H-benzo[d]imidazole-6-carbaldehyde

: 23491-48-7
5-(4-methylpiperazine-1-yl)-2-nitroaniline

: 1268487-56-4
6-(4-methylpiperazin-1-yl)-2'-(4-(prop-2-ynyloxy)phenyl)-1H,3'H-2,5'-bibenzo[d]imidazole

Guidance literature:: 5-(4-methylpiperazine-1-yl)-2-nitroaniline; With palladium 10% on activated carbon; hydrogen; In ethanol; for 6h; under 760.051 Torr;

2-(4-(prop-2-ynyloxy)phenyl)-1H-benzo[d]imidazole-6-carbaldehyde; With sodium metabisulfite; In ethanol; water; for 14h; Reflux;

Reference yield:

: 1268487-54-2
2-(4-(prop-2-ynyloxy)phenyl)-1H-benzo[d]imidazole-6-carbaldehyde

: 54998-08-2
4-(4-methylpiperazino)-1,2-diaminobenzene

: 1268487-56-4
6-(4-methylpiperazin-1-yl)-2'-(4-(prop-2-ynyloxy)phenyl)-1H,3'H-2,5'-bibenzo[d]imidazole

Guidance literature:: With sodium metabisulfite; In water; for 14h; Reflux;
DOI:10.1039/c4md00140k

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1268487-56-4
6-(4-methylpiperazin-1-yl)-2'-(4-(prop-2-ynyloxy)phenyl)-1H,3'H-2,5'-bibenzo[d]imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane; 1,4-dioxane / 0 - 20 °C / Inert atmosphere; Cooling with ice

2: sodium metabisulfite / water / 12 h / Reflux

3: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 6 h / -70 - -20 °C / Inert atmosphere

4: sodium metabisulfite / water / 14 h / Reflux

With sodium metabisulfite; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; 1: |Mitsunobu Displacement;
DOI:10.1039/c4md00140k