(E)-3-(2-(2-chlorobenzyl)-1-oxoisoindolin-6-yl)acrylic acid

Base Information

• Chemical Name: (E)-3-(2-(2-chlorobenzyl)-1-oxoisoindolin-6-yl)acrylic acid
• CAS No.: 914647-03-3
• Molecular Formula: C₁₈H₁₄ClNO₃
• Molecular Weight: 327.767
• Mol file: 914647-03-3.mol

Synonyms:(E)-3-(2-(2-chlorobenzyl)-1-oxoisoindolin-6-yl)acrylic acid

Chemical Property of (E)-3-(2-(2-chlorobenzyl)-1-oxoisoindolin-6-yl)acrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(2-(2-chlorobenzyl)-1-oxoisoindolin-6-yl)acrylic acid

There total 5 articles about (E)-3-(2-(2-chlorobenzyl)-1-oxoisoindolin-6-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(E)-methyl 3-(2-(2-chlorobenzyl)-1-oxoisoindolin-6-yl)acrylate (914646-77-8) → (E)-3-(2-(2-chlorobenzyl)-1-oxoisoindolin-6-yl)acrylic acid (914647-03-3)

Guidance literature:

With hydrogenchloride; acetic acid; Heating;

DOI:10.1016/j.bmc.2006.07.008

Reference yield:

(E)-methyl 5-(2-(methoxycarbonyl)vinyl)-2-methylbenzoate (914646-69-8) → (E)-3-(2-(2-chlorobenzyl)-1-oxoisoindolin-6-yl)acrylic acid (914647-03-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 49 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / Heating

2: 70 percent / triethylamine / methanol / Heating

3: 70 percent / acetic acid; hydrochloric acid / Heating

With hydrogenchloride; N-Bromosuccinimide; acetic acid; triethylamine; dibenzoyl peroxide; In methanol; tetrachloromethane;

DOI:10.1016/j.bmc.2006.07.008

Reference yield:

(E)-methyl 5-(2-(methoxycarbonyl)vinyl)-2-bromomethylbenzoate (914646-71-2) → (E)-3-(2-(2-chlorobenzyl)-1-oxoisoindolin-6-yl)acrylic acid (914647-03-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / triethylamine / methanol / Heating

2: 70 percent / acetic acid; hydrochloric acid / Heating

With hydrogenchloride; acetic acid; triethylamine; In methanol;

DOI:10.1016/j.bmc.2006.07.008

upstream raw materials:

(E)-methyl 3-(2-(2-chlorobenzyl)-1-oxoisoindolin-6-yl)acrylate

(E)-methyl 5-(2-(methoxycarbonyl)vinyl)-2-methylbenzoate

(E)-methyl 5-(2-(methoxycarbonyl)vinyl)-2-bromomethylbenzoate

methyl 5-amino-2-methylbenzoate

Downstream raw materials:

(E)-3-(2-(2-chlorobenzyl)-1-oxoisoindolin-6-yl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide