(1R,2S)-2-(3,4,5-trimethoxybenzoyl)-cyclopentanecarboxylic acid

Base Information

• Chemical Name: (1R,2S)-2-(3,4,5-trimethoxybenzoyl)-cyclopentanecarboxylic acid
• CAS No.: 946007-83-6
• Molecular Formula: C₁₆H₂₀O₆
• Molecular Weight: 308.331
• Mol file: 946007-83-6.mol

Synonyms:(1R,2S)-2-(3,4,5-trimethoxybenzoyl)-cyclopentanecarboxylic acid

Chemical Property of (1R,2S)-2-(3,4,5-trimethoxybenzoyl)-cyclopentanecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (1R,2S)-2-(3,4,5-trimethoxybenzoyl)-cyclopentanecarboxylic acid

There total 1 articles about (1R,2S)-2-(3,4,5-trimethoxybenzoyl)-cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopentane-cis-1,2-dicarboxylic acid anhydride (35878-28-5,743438-34-8) + 1-bromo-3,4,5-trimethoxybenzene (2675-79-8) → (1S,2R)-2-(3,4,5-trimethoxybenzoyl)-cyclopentanecarboxylic acid + (1R,2S)-2-(3,4,5-trimethoxybenzoyl)-cyclopentanecarboxylic acid (946007-83-6)

Guidance literature:

1-bromo-3,4,5-trimethoxybenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

With zinc trifluoromethanesulfonate; In tetrahydrofuran; hexane; at 20 ℃; for 2h;

cyclopentane-cis-1,2-dicarboxylic acid anhydride; chloro(1,5-cyclooctadiene)rhodium(I) dimer; In N,N-dimethyl-formamide; at 20 ℃; for 25h; Further stages. Title compound not separated from byproducts.;

DOI:10.1002/anie.200700816

Reference yield:

(1R,2S)-2-(3,4,5-trimethoxybenzoyl)-cyclopentanecarboxylic acid (946007-83-6) + diazomethyl-trimethyl-silane (18107-18-1) → C17H22O6 (946007-99-4)

Guidance literature:

In methanol; diethyl ether; benzene; at 23 ℃; optical yield given as %ee; Inert atmosphere;

DOI:10.1016/j.tet.2008.10.075

upstream raw materials:

cyclopentane-cis-1,2-dicarboxylic acid anhydride

1-bromo-3,4,5-trimethoxybenzene

Downstream raw materials:

C₁₇H₂₂O₆