2675-79-8

Basic information

• Product Name: 1-Bromo-3,4,5-trimethoxybenzene
• Synonyms: 1-Bromo-3,4,5-trimethoxybenzene 98%;5-Bromopyrogallol trimethyl ether;3,4,5-Trimethoxybrombenzene;3,4,5-Trimethoxyphenyl bromide;5-Bromo-1,2,3-trimethoxybenzene,1-Bromo-3,4,5-trimethoxybenzene;Benzene, 5-bromo-1,2,3-trimethoxy-;5-Bromo-1,2,3-trimethoxybenzene 97%;3,4,5-TRIMETHOXYBROMOBENZENE
• CAS NO: 2675-79-8
• Molecular Formula: C₉H₁₁BrO₃
• Molecular Weight: 247.09
• EINECS: 220-223-9
• Product Categories: Aromatic Ethers;Benzene series;Benzene derivates;Pyrrolidines
• Mol File: 2675-79-8.mol
• Article Data: 18

Chemical Properties

• Melting Point: 78-82 °C(lit.)
• Boiling Point: 273°C/747mmHg(lit.)
• Flash Point: 103.7 °C
• Appearance: off-white crystals
• Density: 1.5463 (rough estimate)
• Vapor Pressure: 0.018mmHg at 25°C
• Refractive Index: 1.4730 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 1-Bromo-3,4,5-trimethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-3,4,5-trimethoxybenzene(2675-79-8)
• EPA Substance Registry System: 1-Bromo-3,4,5-trimethoxybenzene(2675-79-8)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 22-36/37
• WGK Germany: 3
• Hazardous Substances Data: 2675-79-8(Hazardous Substances Data)

Usage

Uses

5-Bromo-1,2,3-trimethoxybenzene is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

InChI:InChI=1/C9H11BrO3/c1-11-7-4-6(10)5-8(12-2)9(7)13-3/h4-5H,1-3H3

Upstream product

• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 91-10-1 1,3-dimethoxy-2-hydroxy-benzene 
• 2539-27-7 3,4,5-tribromo-2,6-dimethoxyphenol 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 38790-07-7 5-bromo-3-methoxybenzene-1,2-diol 
• 616-38-6 carbonic acid dimethyl ester 
• 634-36-6 1,2,3-trimethoxybenzene 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 213596-33-9 2-(4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborolane 
• 70654-71-6 4-bromo-2,6-dimethoxyphenol 
• 16492-75-4 5-bromo-1,2,3 trihydroxybenzene 
• 5034-74-2 5-bromo-3-methoxysalicylaldehyde 
• 77-78-1 dimethyl sulfate 
• 118-41-2 Eudesmic acid 

Downstream Products

• 22480-91-7 (2,3,4-trimethoxy-phenyl)-acetic acid 
• 76284-02-1 2-benzyl-6-exo-hydroxy-6-endo-3',4',5'-trimethoxyphenyl-2-azabicyclo<2.2.2>octane 
• 127404-78-8 4-(3,4,5-trimethoxy-phenyl)-but-3-enoic acid 
• 6443-69-2 3,4,5-trimethoxytoluene 
• 329008-82-4 (3-benzyloxy-4-methoxy-phenyl)-(3,4,5-trimethoxy-phenyl)-amine 
• 404953-19-1 (4R)-4-(diphenylmethyl)-3-[3-(3,3-bis-3',4',5'-trimethoxyphenyl)-propanoyl]-2-oxazolidinone 
• 866002-15-5 (4,5-dimethoxy-2-nitrophenyl)(3,4,5-trimethoxyphenyl)methanol 
• 581069-45-6 6.7-Methylendioxy-1-<3.4.5-trimethoxy-phenyl>-1.2-dihydro-naphthoesaeure-(2)-methylester 
• 182163-96-8 3,4,5-trimethoxyphenylboronic Acid 
• 220230-97-7 3,3',4,4',5,5'-hexamethoxydiphenylacetylene 
• 634-36-6 1,2,3-trimethoxybenzene 
• 915190-54-4 2-(3,4,5-trimethoxyphenyl)-benzo[b]thiophene-3-carbonitrile 
• 915190-58-8 C-[2-(3,4,5-trimethoxyphenyl)benzo[b]thiophen-3-yl]methylamine 

Relevant articles and documents

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Synthetic method 5 - bromo -1 and 2,3 - trimethoxy benzene

The synthesis method of 5 -bromo -1-2,3 -methoxy benzene comprises the following steps: S1, taking the vanillin as a starting raw material, and brominating 5 - bromo -2 - hydroxyl -3 -methoxybenzaldehyde through the hydroxyl group para-position. S2 is obt

New procedure for the highly regioselective aerobic bromination of aromatic compounds using copper-based nanocatalyst

A new procedure for the highly regioselective aerobic bromination of aromatic compounds in the presence of copper-based nanoparticles (CuO/ZnO nanocatalyst) under reflux condition is described. Mechanistic parameters are discussed and the plausible mechanism is proposed. Recyclability of the CuO/ZnO nanocatalyst has also been explored upon aerobic bromination of aromatic compounds.

Predicting the structure of supramolecular dendrimers via the analysis of libraries of AB3 and constitutional isomeric AB2 biphenylpropyl ether self-assembling dendrons

The synthesis of 4′-hydroxy-4-biphenylpropionic, 3′,4′- dihydroxy-4-biphenylpropionic, 3′,5′-dihydroxy-4-biphenylpropionic, and 3′,4′,5′-trihydroxy-4-biphenylpropionic methyl esters via three efficient and modular strategies including one based on Ni-catalyzed borylation and sequential cross-coupling is reported. These building blocks were employed in a convergent iterative approach to the synthesis of one library of 3,4,5-trisubstituted and two libraries of constitutional isomeric 3,4- and 3,5-disubstituted biphenylpropyl ether dendrons. Structural and retrostructural analysis of supramolecular dendrimers revealed that biphenylpropyl ether dendrons self-assemble and self-organize into the same periodic lattices and quasi-periodic arrays observed in previously reported libraries, but with larger dimensions, different mechanisms of self-assembly, and improved solubility, thermal, acidic, and oxidative stability. The different mechanisms of self-assembly led to the discovery of two new supramolecular structures. The first represents a new banana-like lamellar crystal with a four layer repeat. The second is a giant vesicular sphere self-assembled from 770 dendrons that exhibits an ultrahigh molar mass of 1.73 × 106 g/mol. Thus, the enhanced size of the self-assembled structures constructed from biphenylpropyl ether dendrons permitted for the first time discrimination of various molecular mechanisms of spherical self-assembly and elaborated a continuum between small filled spheres and very large hollow spheres that is dictated by the primary structure of the dendron. The comparative analysis of libraries of biphenylpropyl ether dendrons with the previously reported libraries of benzyl-, phenylpropyl-, and biphenyl-4-methyl ether dendrons demonstrated biomimetic self-assembly wherein the primary structure of the dendron and to a lesser extent the structure of its repeat unit determines the supramolecular tertiary structure. A "nanoperiodic table" of self-assembling dendrons and supramolecular dendrimers that allows the prediction of the general features of tertiary structures from primary structures was elaborated.