4-[1-Methoxy-meth-(E)-ylidene]-3-(3-methoxy-phenyl)-4,5,6,7-tetrahydro-benzo[d]isoxazole

Base Information

Chemical Name:4-[1-Methoxy-meth-(E)-ylidene]-3-(3-methoxy-phenyl)-4,5,6,7-tetrahydro-benzo[d]isoxazole
CAS No.:501838-23-9
Molecular Formula:C₁₆H₁₇NO₃
Molecular Weight:271.316
Hs Code.:

Synonyms:4-[1-Methoxy-meth-(E)-ylidene]-3-(3-methoxy-phenyl)-4,5,6,7-tetrahydro-benzo[d]isoxazole

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Chemical Property of 4-[1-Methoxy-meth-(E)-ylidene]-3-(3-methoxy-phenyl)-4,5,6,7-tetrahydro-benzo[d]isoxazole

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Technology Process of 4-[1-Methoxy-meth-(E)-ylidene]-3-(3-methoxy-phenyl)-4,5,6,7-tetrahydro-benzo[d]isoxazole

There total 3 articles about 4-[1-Methoxy-meth-(E)-ylidene]-3-(3-methoxy-phenyl)-4,5,6,7-tetrahydro-benzo[d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 4455-77-0
(methoxymethyl)diphenylphosphine oxide

: 169814-25-9
3-(3-methoxy-phenyl)-6,7-dihydro-5H-benzo[d]isoxazol-4-one

: 501838-23-9
4-[1-Methoxy-meth-(E)-ylidene]-3-(3-methoxy-phenyl)-4,5,6,7-tetrahydro-benzo[d]isoxazole

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/ol027283f

Reference yield:

: 38489-80-4
3-methoxybenzaldehyde oxime

: 501838-23-9
4-[1-Methoxy-meth-(E)-ylidene]-3-(3-methoxy-phenyl)-4,5,6,7-tetrahydro-benzo[d]isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: NCS / pyridine / CHCl₃ / 3 h / 40 °C

2: 64 percent / sodium isopropoxide / propan-2-ol / 0.5 h / 20 °C

3: 45 percent / LDA / tetrahydrofuran

With N-chloro-succinimide; sodium isopropylate; lithium diisopropyl amide; pyridine; In tetrahydrofuran; chloroform; isopropyl alcohol;
DOI:10.1021/ol027283f

Reference yield:

: 76272-16-7
N-hydroxy-3-(methyloxy)benzenecarboximidoyl chloride

: 501838-23-9
4-[1-Methoxy-meth-(E)-ylidene]-3-(3-methoxy-phenyl)-4,5,6,7-tetrahydro-benzo[d]isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / sodium isopropoxide / propan-2-ol / 0.5 h / 20 °C

2: 45 percent / LDA / tetrahydrofuran

With sodium isopropylate; lithium diisopropyl amide; In tetrahydrofuran; isopropyl alcohol;
DOI:10.1021/ol027283f